The role of protein synthesis and digestive enzymes in acinar cell injury.
The role of protein synthesis and digestive enzymes in acinar cell injury.
复制标题
DOI：
10.1038/nrgastro.2013.36
复制
发表时间：
2013-06
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
胰腺的外分泌是成人体内蛋白质合成水平最高的器官，每天胰腺都会产生大量的液体，这些液体中充满了能够分解几乎所有有机物质的酶。为了达到最佳健康状态，胰腺必须产生足够的正确特性的酶，以匹配饮食摄入量。正常胰腺功能的破坏主要是由于产生这些消化酶的腺泡细胞功能障碍而发生的，并且可以导致急性或慢性疾病。多年来，流行的教条一直是腺泡细胞产生的消化酶的不适当的细胞内激活是胰腺炎性疾病的关键，因为消化酶本身对分泌它们的细胞有潜在的危害。然而，我们现在知道，许多应激源可以影响胰腺腺泡细胞，并且这些应激源可以通过各种机制独立地触发胰腺病理。这篇综述集中于蛋白质合成和活性消化酶--腺泡细胞所面临的两个关键压力源，这两个压力源可能是胰腺病理学的主要驱动因素。
The exocrine pancreas is the organ with the highest level of protein synthesis in the adult—each day the pancreas produces litres of fluid filled with enzymes that are capable of breaking down nearly all organic substances. For optimal health, the pancreas must produce sufficient enzymes of the right character to match the dietary intake. Disruption of normal pancreatic function occurs primarily as a result of dysfunction of the acinar cells that produce these digestive enzymes, and can lead to acute or chronic diseases. For many years, the prevailing dogma has been that inappropriate intracellular activation of the digestive enzymes produced by acinar cells was the key to pancreatic inflammatory diseases, as digestive enzymes themselves are potentially harmful to the cells that secrete them. However, we now know that many stressors can affect pancreatic acinar cells, and that these stressors can independently trigger pancreatic pathology through various mechanisms. This Review focuses on protein synthesis and active digestive enzymes—two key stressors faced by the acinar cell that are likely to be the major drivers of pathology encountered in the pancreas.
登录
查看更多内容
影响因子：
15.9
作者：
Halangk, W;Lerch, MM;Deussing, J
通讯作者：
Deussing, J
影响因子：
3.5
作者：
Belal, Cherine;Ameli, Neema J.;Chan, Sic L.
通讯作者：
Chan, Sic L.
DOI：
10.1152/ajpgi.00315.2001
发表时间：
2002-02-01
影响因子：
4.5
作者：
Halangk, W;Krüger, B;Lerch, MM
通讯作者：
Lerch, MM
影响因子：
10.7
作者：
Chen, JM;Kukor, Z;Sahin-Tóth, M
通讯作者：
Sahin-Tóth, M
影响因子：
--
作者：
GREEN, GM;JURKOWSKA, G;MORISSET, J
通讯作者：
MORISSET, J