Association between periodontitis and severity of COVID-19 infection: A case-control study.
Association between periodontitis and severity of COVID-19 infection: A case-control study.
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DOI：
10.1111/jcpe.13435
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发表时间：
2021-04
影响因子：
6.7
通讯作者：
Tamimi F
中科院分区：
文献类型：
--
作者：
Marouf N;Cai W;Said KN;Daas H;Diab H;Chinta VR;Hssain AA;Nicolau B;Sanz M;Tamimi F
新冠肺炎与炎症反应加剧有关，可能导致致命后果。全身性炎症也是牙周炎的主要特征。因此，我们调查了牙周炎与新冠肺炎并发症的关系。2020年2月至7月，使用卡塔尔国的国家电子健康记录进行了一项病例对照研究。病例定义为发生新冠肺炎并发症(死亡、入院ICU或辅助呼吸机)的患者，对照组为无重大并发症的新冠肺炎患者出院。使用同一数据库中的牙科X光片评估牙周状况。牙周炎和COVID19并发症之间的关系通过对人口统计学、医学和行为因素进行调整的Logistic回归模型进行了分析。总共有568名患者纳入研究。在调整潜在混杂因素后，牙周炎与新冠肺炎并发症有关，包括死亡(OR=88.81，95%CI为1.00~77.7)、住ICU(OR=354，95%CI为1.39~9.05)和需要辅助通气(OR=457，95%CI为1.19~17.4)。同样，新冠肺炎牙周炎患者的血液中白细胞、D-二聚体和C反应蛋白水平也显著高于对照组。牙周炎与ICU入院的风险、需要辅助呼吸和新冠肺炎患者的死亡有关，并与血液中与更差的疾病结局有关的生物标志物水平升高有关。
COVID‐19 is associated with an exacerbated inflammatory response that can result in fatal outcomes. Systemic inflammation is also a main characteristic of periodontitis. Therefore, we investigated the association of periodontitis with COVID‐19 complications. A case–control study was performed using the national electronic health records of the State of Qatar between February and July 2020. Cases were defined as patients who suffered COVID‐19 complications (death, ICU admissions or assisted ventilation), and controls were COVID‐19 patients discharged without major complications. Periodontal conditions were assessed using dental radiographs from the same database. Associations between periodontitis and COVID 19 complications were analysed using logistic regression models adjusted for demographic, medical and behaviour factors. In total, 568 patients were included. After adjusting for potential confounders, periodontitis was associated with COVID‐19 complication including death (OR = 8.81, 95% CI 1.00–77.7), ICU admission (OR = 3.54, 95% CI 1.39–9.05) and need for assisted ventilation (OR = 4.57, 95% CI 1.19–17.4). Similarly, blood levels of white blood cells, D‐dimer and C Reactive Protein were significantly higher in COVID‐19 patients with periodontitis. Periodontitis was associated with higher risk of ICU admission, need for assisted ventilation and death of COVID‐19 patients, and with increased blood levels of biomarkers linked to worse disease outcomes.
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DOI：
10.15557/pimr.2020.0003
发表时间：
2020-01-01
影响因子：
3.6
作者：
通讯作者：
--
影响因子：
5.4
作者：
LaMonte MJ;Genco RJ;Hovey KM;Wallace RB;Freudenheim JL;Michaud DS;Mai X;Tinker LF;Salazar CR;Andrews CA;Li W;Eaton CB;Martin LW;Wactawski-Wende J
通讯作者：
Wactawski-Wende J
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
6.7
作者：
Chambrone, Leandro;Foz, Adriana M.;Romito, Giuseppe A.
通讯作者：
Romito, Giuseppe A.
影响因子：
5.5
作者：
Botros, Nathalie;Iyer, Parvati;Ojcius, David M.
通讯作者：
Ojcius, David M.