Neurological and neurobehavioral assessment of experimental subarachnoid hemorrhage.
Neurological and neurobehavioral assessment of experimental subarachnoid hemorrhage.
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DOI：
10.1186/1471-2202-10-103
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发表时间：
2009-08-25
期刊：
影响因子：
2.4
通讯作者：
Macdonald RL
中科院分区：
文献类型：
--
作者：
Jeon H;Ai J;Sabri M;Tariq A;Shang X;Chen G;Macdonald RL
动脉瘤性蛛网膜下腔出血（SAH）患者约有50%死亡，许多幸存者有神经和神经行为功能障碍。动物研究通常集中在脑血管痉挛和有时神经元损伤。终点的差异可能导致缺乏对动物有效的治疗方法转化为人类。我们回顾了先前的SAH动物研究，以确定使用了哪些神经和神经行为终点，它们是否区分了适当的对照组和SAH动物，是否报道了治疗效果以及它们是否与血管痉挛相关。只有少数对老鼠的研究考察了学习和记忆。结论是，需要更多的研究来充分表征SAH动物的神经行为表现并评估治疗效果。
About 50% of humans with aneurysmal subarachnoid hemorrhage (SAH) die and many survivors have neurological and neurobehavioral dysfunction. Animal studies usually focused on cerebral vasospasm and sometimes neuronal injury. The difference in endpoints may contribute to lack of translation of treatments effective in animals to humans. We reviewed prior animal studies of SAH to determine what neurological and neurobehavioral endpoints had been used, whether they differentiated between appropriate controls and animals with SAH, whether treatment effects were reported and whether they correlated with vasospasm. Only a few studies in rats examined learning and memory. It is concluded that more studies are needed to fully characterize neurobehavioral performance in animals with SAH and assess effects of treatment.
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影响因子：
8.3
作者：
BEDERSON, JB;PITTS, LH;BARTKOWSKI, H
通讯作者：
BARTKOWSKI, H
影响因子：
2
作者：
Aoki, K;Zubkov, AY;Zhang, JH
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Zhang, JH
影响因子：
4.8
作者：
Cahill, Julian;Calvert, John W.;Zhang, John H.
通讯作者：
Zhang, John H.
影响因子：
4.1
作者：
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通讯作者：
Zuccarello, Mario
影响因子：
4.4
作者：
Bermueller, C;Thal, SC;Zausinger, S
通讯作者：
Zausinger, S