Relationships of gut microbiota, short-chain fatty acids, inflammation, and the gut barrier in Parkinson's disease.
Relationships of gut microbiota, short-chain fatty acids, inflammation, and the gut barrier in Parkinson's disease.
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DOI：
10.1186/s13024-021-00427-6
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发表时间：
2021-02-08
影响因子：
15.1
通讯作者：
Scheperjans F
中科院分区：
文献类型：
--
作者：
Aho VTE;Houser MC;Pereira PAB;Chang J;Rudi K;Paulin L;Hertzberg V;Auvinen P;Tansey MG;Scheperjans F
以前的研究已经报道，肠道微生物群，渗透性，短链脂肪酸（SCFAs）和炎症在帕金森病（PD）中发生了改变，但这些因素如何联系以及它们如何促进疾病过程和症状仍然不确定。本研究旨在比较和确定这些因素在PD患者和对照组之间的关联，以阐明其相互关系和PD的临床表现的联系。从55名PD患者和56名对照中收集粪便和血浆样本以及临床数据。在患者和对照组之间比较粪便SCFAs和粪便以及血浆炎症和渗透性标志物的水平，并将其相互关联并与肠道微生物群关联。PD患者粪便中钙卫蛋白升高，SCFAs降低，呈性别依赖性。血浆和粪便中的炎症标志物与SCFA水平既不相关也不密切相关。PD发病年龄与SCFAs呈正相关，与CXCL 8和IL-1β呈负相关。粪便带状蛋白与粪便NGAL呈正相关，与PD运动和非运动症状呈负相关。微生物群的多样性和组成与粪便中SCFA，炎症因子和zonulin的水平有关。患者和对照组之间以及性别之间的某些关系存在差异。肠道炎症反应和粪便SCFA的减少发生在PD中，与微生物群和疾病发作相关，并且不反映在血浆炎症特征中。其中一些关系在PD中是不同的，并且是性别依赖的。这项研究揭示了微生物-宿主相互作用的潜在变化以及早期PD发作和肠道炎症反应之间的联系，并降低了SCFA水平，突出了可能有助于PD发病机制和临床表现的候选分子和途径，并需要进一步研究。在线版本包含补充材料，可通过10.1186/s13024-021-00427-6获得。
Previous studies have reported that gut microbiota, permeability, short-chain fatty acids (SCFAs), and inflammation are altered in Parkinson’s disease (PD), but how these factors are linked and how they contribute to disease processes and symptoms remains uncertain. This study sought to compare and identify associations among these factors in PD patients and controls to elucidate their interrelations and links to clinical manifestations of PD. Stool and plasma samples and clinical data were collected from 55 PD patients and 56 controls. Levels of stool SCFAs and stool and plasma inflammatory and permeability markers were compared between patients and controls and related to one another and to the gut microbiota. Calprotectin was increased and SCFAs decreased in stool in PD in a sex-dependent manner. Inflammatory markers in plasma and stool were neither intercorrelated nor strongly associated with SCFA levels. Age at PD onset was positively correlated with SCFAs and negatively correlated with CXCL8 and IL-1β in stool. Fecal zonulin correlated positively with fecal NGAL and negatively with PD motor and non-motor symptoms. Microbiota diversity and composition were linked to levels of SCFAs, inflammatory factors, and zonulin in stool. Certain relationships differed between patients and controls and by sex. Intestinal inflammatory responses and reductions in fecal SCFAs occur in PD, are related to the microbiota and to disease onset, and are not reflected in plasma inflammatory profiles. Some of these relationships are distinct in PD and are sex-dependent. This study revealed potential alterations in microbiota-host interactions and links between earlier PD onset and intestinal inflammatory responses and reduced SCFA levels, highlighting candidate molecules and pathways which may contribute to PD pathogenesis and clinical presentation and which warrant further investigation. The online version contains supplementary material available at 10.1186/s13024-021-00427-6.
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影响因子：
30.3
作者：
Kelly CJ;Zheng L;Campbell EL;Saeedi B;Scholz CC;Bayless AJ;Wilson KE;Glover LE;Kominsky DJ;Magnuson A;Weir TL;Ehrentraut SF;Pickel C;Kuhn KA;Lanis JM;Nguyen V;Taylor CT;Colgan SP
通讯作者：
Colgan SP
DOI：
10.1002/mds.27326
发表时间：
2018-05
期刊：
Movement disorders : official journal of the Movement Disorder Society
影响因子：
--
作者：
Houser MC;Chang J;Factor SA;Molho ES;Zabetian CP;Hill-Burns EM;Payami H;Hertzberg VS;Tansey MG
通讯作者：
Tansey MG
影响因子：
7.3
作者：
Chen X;Hu Y;Cao Z;Liu Q;Cheng Y
通讯作者：
Cheng Y
影响因子：
9.3
作者：
Eidson LN;Kannarkat GT;Barnum CJ;Chang J;Chung J;Caspell-Garcia C;Taylor P;Mollenhauer B;Schlossmacher MG;Ereshefsky L;Yen M;Kopil C;Frasier M;Marek K;Hertzberg VS;Tansey MG
通讯作者：
Tansey MG
影响因子：
3.7
作者：
Hasegawa S;Goto S;Tsuji H;Okuno T;Asahara T;Nomoto K;Shibata A;Fujisawa Y;Minato T;Okamoto A;Ohno K;Hirayama M
通讯作者：
Hirayama M