Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin.
Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin.
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DOI：
10.1186/ar1733
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发表时间：
2005
影响因子：
4.9
通讯作者：
Salmon M
中科院分区：
文献类型：
--
作者：
Raza K;Falciani F;Curnow SJ;Ross EJ;Lee CY;Akbar AN;Lord JM;Gordon C;Buckley CD;Salmon M
类风湿性滑膜炎发病的病理过程尚不清楚。我们进行了目前的研究，以确定免疫和基质的过程，目前在类风湿性关节炎（RA）的临床发病后不久，通过评估一组T细胞，巨噬细胞和基质细胞相关的细胞因子和趋化因子在早期滑膜炎患者的滑液。从持续时间3个月或更短的炎性关节炎患者的发炎关节抽吸滑液，随后通过随访确定其结果。为了比较，从急性结晶性关节炎、确诊的RA和骨关节炎患者中抽取滑液。在滑液样品中阻断风湿因子活性，并使用基于多重的系统测量一组23种细胞因子和趋化因子。早期炎性关节炎患者随后发展为RA，其滑液细胞因子谱明显但短暂。与未发生RA的早期关节炎患者相比，这些患者在症状发作后3个月内的一系列T细胞、巨噬细胞和基质细胞相关细胞因子（例如IL-2、IL-4、IL-13、IL-17、IL-15、碱性成纤维细胞生长因子和表皮生长因子）的水平显著升高。此外，在已确立的RA中不再存在该特征。相比之下，非类风湿性持续性滑膜炎患者在开始时表现出干扰素-γ水平升高。因此，注定发展成RA的早期滑膜炎的特征在于独特的和短暂的滑液细胞因子谱。早期类风湿性病变中存在的细胞因子表明，这种反应可能会影响持续性RA所需的微环境。
Pathological processes involved in the initiation of rheumatoid synovitis remain unclear. We undertook the present study to identify immune and stromal processes that are present soon after the clinical onset of rheumatoid arthritis (RA) by assessing a panel of T cell, macrophage, and stromal cell related cytokines and chemokines in the synovial fluid of patients with early synovitis. Synovial fluid was aspirated from inflamed joints of patients with inflammatory arthritis of duration 3 months or less, whose outcomes were subsequently determined by follow up. For comparison, synovial fluid was aspirated from patients with acute crystal arthritis, established RA and osteoarthritis. Rheumatoid factor activity was blocked in the synovial fluid samples, and a panel of 23 cytokines and chemokines measured using a multiplex based system. Patients with early inflammatory arthritis who subsequently developed RA had a distinct but transient synovial fluid cytokine profile. The levels of a range of T cell, macrophage and stromal cell related cytokines (e.g. IL-2, IL-4, IL-13, IL-17, IL-15, basic fibroblast growth factor and epidermal growth factor) were significantly elevated in these patients within 3 months after symptom onset, as compared with early arthritis patients who did not develop RA. In addition, this profile was no longer present in established RA. In contrast, patients with non-rheumatoid persistent synovitis exhibited elevated levels of interferon-γ at initiation. Early synovitis destined to develop into RA is thus characterized by a distinct and transient synovial fluid cytokine profile. The cytokines present in the early rheumatoid lesion suggest that this response is likely to influence the microenvironment required for persistent RA.
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在已建立的II型胶原蛋白诱导的关节炎中，全身性白介素4治疗对软骨和骨骼破坏的保护。
DOI：
10.1186/ar14
发表时间：
1999
期刊：
Arthritis research
影响因子：
--
作者：
Joosten, L A;Lubberts, E;Helsen, M M;Saxne, T;Coenen-de Roo , C J;Heinegard, D;van den Berg , W B
通讯作者：
van den Berg , W B
影响因子：
16.8
作者：
Buckley, CD;Pilling, D;Salmon, M
通讯作者：
Salmon, M
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
--
作者：
Blades, MC;Ingegnoli, F;Pitzalis, C
通讯作者：
Pitzalis, C
影响因子：
--
作者：
Conaghan, PG;O'Connor, P;Emery, P
通讯作者：
Emery, P