Clinical outcomes of patients with clear cell and endometrioid ovarian cancer arising from endometriosis.
Clinical outcomes of patients with clear cell and endometrioid ovarian cancer arising from endometriosis.
复制标题
DOI：
10.3802/jgo.2018.29.e18
复制
发表时间：
2018-03
影响因子：
3.9
通讯作者：
Lee JW
中科院分区：
文献类型：
--
作者：
Paik ES;Kim TJ;Choi CH;Kim BG;Bae DS;Lee JW
本研究的目的是比较卵巢透明细胞癌（CCC）和子宫内膜样癌（EC）中子宫内膜异位症引起的癌症患者的预后。本研究回顾性调查了2001年至2015年在三星医疗中心接受治疗的224例CCC和EC患者，根据Sampson和Scott标准确定子宫内膜异位症引起的癌症。根据分期、年龄、淋巴结转移（LNM）、癌抗原(CA)-125水平、减容手术后残留状态，采用倾向评分匹配法比较子宫内膜异位症患者与非子宫内膜异位症患者（比例为1:1）。子宫内膜异位症45例，无子宫内膜异位症179例。子宫内膜异位症引起的CCC和EC往往表现为年龄较早（平均45.2岁对49.2岁，p=0.003），早期（I期和II期，92.7%对62.3%,p<0.001）， CA-125水平较低（平均307.1对556.7,p=0.041），术后无明显残留疾病的比例较高（87.8%对56.8%,p=0.001），阴性LNM的比例较高（82.9%对59.0%,p=0.008）。无进展生存期（PFS）和总生存期（OS）的Kaplan-Meier曲线显示，子宫内膜异位症引起的癌症组的预后更好（PFS =0.014, OS =0.010）。然而，在多变量分析中，与子宫内膜异位症的关联并不显著。同样，在倾向评分匹配后，两组之间的生存差异无统计学意义。子宫内膜异位症引起的CCC和EC在较早的年龄和阶段被诊断出来。然而，由子宫内膜异位症引起的癌症并不是一个重要的预后因素。
The aim of this investigation is to compare outcomes of patients according to the presence of cancer arising from endometriosis in ovarian clear cell carcinoma (CCC) and endometrioid carcinoma (EC). This study retrospectively investigated 224 CCC and EC patients treated in Samsung Medical Center from 2001 to 2015 to identify cancer arising from endometriosis according to Sampson and Scott criteria. Propensity score matching was performed to compare patients arising from endometriosis to patients without endometriosis (ratio 1:1) according to stage, age, lymph node metastasis (LNM), cancer antigen (CA)-125 level, and residual status after debulking surgery. Forty-five cases arising from endometriosis were compared with 179 cases without endometriosis. CCC and EC arising from endometriosis tended to present with early age (mean, 45.2 vs. 49.2 years; p=0.003), early-stage (stages I and II, 92.7% vs. 62.3%; p<0.001), lower CA-125 level (mean, 307.1 vs. 556.7; p=0.041), higher percentages of no gross residual disease after surgery (87.8% vs.56.8%; p=0.001), and higher percentages of negative LNM (82.9% vs. 59.0%; p=0.008) compared to cases without endometriosis. Kaplan-Meier curves for progression-free survival (PFS) and overall survival (OS) showed better outcomes for groups with cancer arising from endometriosis (p=0.014 for PFS; and p=0.010 for OS). However, the association with endometriosis was not significant in multivariate analysis. Also, after propensity score matching, survival differences between the 2 groups were not significant. CCC and EC arising from endometriosis are diagnosed at an earlier age and stage. However, cancer arising from endometriosis was not a significant prognostic factor.
登录
查看更多内容
影响因子：
2
作者：
Gadducci, Angiolo;Lanfredini, Nora;Tana, Roberta
通讯作者：
Tana, Roberta
DOI：
10.1097/pas.0b013e3181cf3d79
发表时间：
2010-03
期刊：
The American journal of surgical pathology
影响因子：
--
作者：
Kurman RJ;Shih IeM
通讯作者：
Shih IeM
影响因子：
8.8
作者：
Kim, H. S.;Kim, T. H.;Chung, H. H.;Song, Y. S.
通讯作者：
Song, Y. S.
卵巢上皮癌合并盆腔子宫内膜异位症的临床分析
影响因子：
9.8
作者：
Wang, Shu;Qiu, Lin;Wu, Ming
通讯作者：
Wu, Ming
影响因子：
3.7
作者：
Kim, Hee Seung;Kim, Min A.;Song, Yong Sang
通讯作者：
Song, Yong Sang