Modeling and reasoning with qualitative comparative clinical knowledge

Modeling and reasoning with qualitative comparative clinical knowledge
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利用定性比较临床知识进行建模和推理

DOI:
10.1002/int.20445
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发表时间:
2011
影响因子:
7
通讯作者:
Ma J
Ma J
中科院分区:
计算机科学2区
文献类型:
--
作者:
Ma J

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由于大量临床试验正在进行,临床试验报告数量迅速增加;因此,迫切需要利用临床试验报告中包含的临床知识。在本文中,我们关注的是定性知识而不是定量知识。更准确地说,我们的目标是用定性比较(简称QC)关系来建模和推理,这种关系从临床角度定性地考虑一种药物/治疗比另一种药物/治疗更受欢迎的程度。为此,首先形式化了QC关系,介绍了QC语言、QC库和QC配置文件的概念;其次,我们提出了一套QC关系的归纳规则,并对QC库进行了分级解释,展示了如何确定QC库是否一致。此外,当一个QC库不一致时,我们分析了如何测量QC库之间的不一致性,并提出了合并多个QC库的不同方法。最后,以一个降低眼压的案例来说明我们的方法。©2010 Wiley期刊公司
The number of clinical trials reports is increasing rapidly due to a large number of clinical trials being conducted; it, therefore, raises an urgent need to utilize the clinical knowledge contained in the clinical trials reports. In this paper, we focus on the qualitative knowledge instead of quantitative knowledge. More precisely, we aim to model and reason with the qualitative comparison (QC for short) relations which consider qualitatively how strongly one drug/therapy is preferred to another in a clinical point of view. To this end, first, we formalize the QC relations, introduce the notions of QC language, QC base, and QC profile; second, we propose a set of induction rules for the QC relations and provide grading interpretations for the QC bases and show how to determine whether a QC base is consistent. Furthermore, when a QC base is inconsistent, we analyze how to measure inconsistencies among QC bases, and we propose different approaches to merging multiple QC bases. Finally, a case study on lowering intraocular pressure is conducted to illustrate our approaches. © 2010 Wiley Periodicals, Inc.
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