Microinfarcts, brain atrophy, and cognitive function: the Honolulu Asia Aging Study Autopsy Study.
Microinfarcts, brain atrophy, and cognitive function: the Honolulu Asia Aging Study Autopsy Study.
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DOI：
10.1002/ana.22520
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发表时间：
2011-11
影响因子：
11.2
通讯作者：
White, Lon R.
中科院分区：
文献类型：
--
作者：
Launer, Lenore J.;Hughes, Timothy M.;White, Lon R.
研究微梗死（MBI）与生前整体认知功能（CF）的关系，并探讨脑重量（BW）、阿尔茨海默病（Alzheimer's diseases，NFT）或神经炎性斑块（NP）是否介导了这种关系。受试者是来自檀香山亚洲老龄化尸检研究的437名特征良好的男性死者。用标准化方法确定脑病理学，用认知能力筛查仪（CASI）测量CF，并使用正式的中介分析对数据进行分析，调整死亡年龄，最后一次CF测量与死亡之间的时间，教育和头部大小。根据生前诊断，痴呆和非痴呆受试者一起和单独检查。在那些没有痴呆的人中，MBI与最后一次死亡前CF评分密切相关;这是由BW显著介导的，而不是NFT或NP。相反，在那些生前诊断为痴呆的人中，NFT与BW和CF的相关性最强，而MIB与CF的相关性较低。这表明微梗死病理学是导致脑萎缩和认知障碍的重要和独立因素，特别是在痴呆临床明显之前。血管损伤作为神经退行性变的起始物、刺激物或添加剂的作用可能因病变发展到痴呆的轨迹而异。
To study the association of microinfarcts (MBI) to ante-mortem global cognitive function (CF), and to investigate whether brain weight (BW), Alzheimer’s lesions (neurofibrillary tangles (NFT) or neuritic plaques (NP) mediate the association. Subjects are 437 well-characterized male decedents from the Honolulu Asia Aging Autopsy Study. Brain pathology was ascertained with standardized methods, CF was measured by the Cognitive Abilities Screening Instrument (CASI)and data were analyzed using formal mediation analyses, adjusted for age at death, time between last CF measure and death, education, and head size. Based on ante-mortem diagnoses, demented and non-demented subjects were examined together and separately. In those with no dementia, MBI were strongly associated with the last ante-mortem CF score; this was significantly mediated by BW, and not NFT or NP. In contrast, among those with an ante-mortem diagnosis of dementia, NFT had the strongest associations with BW and with CF, and MIB were modestly associated with CF. This suggests microinfarct pathology is a significant and independent factor contributing to brain atrophy and cognitive impairment, particularly before dementia is clinically evident. The role of vascular damage as initiator, stimulator, or additive contributor to neurodegeneration may differ depending on when in the trajectory towards dementia the lesions develop.
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影响因子：
11.2
作者：
Petrovitch, H;Ross, GW;White, LR
通讯作者：
White, LR
影响因子：
4
作者：
White, Lon
通讯作者：
White, Lon
影响因子：
3.3
作者：
Hoyer, S
通讯作者：
Hoyer, S
影响因子：
4.4
作者：
Fernando, MS;Ince, PG
通讯作者：
Ince, PG
影响因子：
5.4
作者：
Preacher, Kristopher J.;Hayes, Andrew F.
通讯作者：
Hayes, Andrew F.