Understanding the contextual functions of C1q and LAIR-1 and their applications.
Understanding the contextual functions of C1q and LAIR-1 and their applications.
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DOI：
10.1038/s12276-022-00774-4
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发表时间：
2022-05
影响因子：
12.8
通讯作者：
Son M
中科院分区：
文献类型：
--
作者：
Son M
补体成分C1q在自身免疫、感染、炎症性疾病和肿瘤中的重要性已被强调。C1q独特的郁金香状结构具有胶原样茎（C1q尾）和异源三聚体球状头（gC1q），各自具有不同的结合特异性，这些成分与各自受体的结合导致体内功能复杂性，并连接先天和适应性免疫。本文介绍了C1q在各种微环境中的基本作用，并重点介绍了C1q及其受体与抑制受体LAIR-1相互作用在维持体内平衡中的重要性。目前的治疗机会调节LAIR-1也进行了讨论。对C1q蛋白活性的研究揭示了该蛋白作用的新细节，并开辟了可能的新治疗机会。C1q蛋白参与了被称为补体激活的免疫反应的一系列分子相互作用。美国曼哈塞特范斯坦医学研究所的Myoungsun Son综述了C1q在感染、自身免疫、炎症性疾病和肿瘤中的作用。C1q与一种叫做LAIR-1的受体蛋白的相互作用似乎特别重要。LAIR-1存在于大多数造血细胞的膜中，参与维持被称为体内平衡的细胞活动的健康平衡。新兴研究表明，针对C1q和LAIR-1之间的相互作用，可以开发出许多疾病的新疗法，包括炎症性疾病、自身免疫性疾病狼疮、各种癌症，甚至可能包括Covid-19。
The importance of the complement component C1q has been highlighted by its involvement in autoimmunity, infection, inflammatory diseases, and tumors. The unique tulip-like structure of C1q has both a collagen-like stalk (C1q tail) and heterotrimeric globular head (gC1q), each with different binding specificities, and the binding of these components to their respective receptors leads to functional complexities in the body and bridges innate and adaptive immunity. This review describes the fundamental roles of C1q in various microenvironments and focuses on the importance of the interactions of C1q and its receptors with the inhibitory receptor LAIR-1 in maintaining homeostasis. Current therapeutic opportunities modulating LAIR-1 are also discussed. Research into the activities of the protein C1q, involved in a cascade of molecular interactions of the immune response called complement activation, is revealing new details of the protein’s role and opening up possible new therapeutic opportunities. Myoungsun Son at Feinstein Institutes for Medical Research in Manhasset, USA, reviews the involvement of C1q in infection, autoimmunity, inflammatory diseases and tumors. The interaction of C1q with a receptor protein called LAIR-1 seems to be particularly significant. LAIR-1 is present in the membrane of most blood-forming cells and is involved in maintaining the healthy balance of cellular activities referred to as homeostasis. Emerging research suggests that targeting the interactions between C1q and LAIR-1 could enable the development of new treatments for many diseases, including inflammatory diseases, the autoimmune condition lupus, a variety of cancers, and possibly Covid-19.
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影响因子：
3.7
作者：
Colombo BM;Canevali P;Magnani O;Rossi E;Puppo F;Zocchi MR;Poggi A
通讯作者：
Poggi A
影响因子：
4.8
作者：
Abbonante, Vittorio;Gruppi, Cristian;Balduini, Alessandra
通讯作者：
Balduini, Alessandra
影响因子：
12.8
作者：
Franchin G;Son M;Kim SJ;Ben-Zvi I;Zhang J;Diamond B
通讯作者：
Diamond B
影响因子：
5.5
作者：
Fraser, Deborah A.;Bohlson, Suzanne S.;Tenner, Andrea J.
通讯作者：
Tenner, Andrea J.
影响因子：
5.3
作者：
Galvan, Manuel D.;Hulsebus, Holly;Bohlson, Suzanne S.
通讯作者：
Bohlson, Suzanne S.