The Proportion of Regulatory T Cells in Patients with Rheumatoid Arthritis: A Meta-Analysis.
The Proportion of Regulatory T Cells in Patients with Rheumatoid Arthritis: A Meta-Analysis.
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DOI：
10.1371/journal.pone.0162306
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Kumanogoh A
中科院分区：
文献类型：
--
作者：
Morita T;Shima Y;Wing JB;Sakaguchi S;Ogata A;Kumanogoh A
调节性T细胞（Regulatory T cells，Tcells）在外周免疫耐受中具有重要作用。甲状腺功能障碍被认为是自身免疫性疾病，包括类风湿性关节炎（RA）的关键原因。然而，以前的报告描述了RA患者中CD 4 + T细胞中TcB的比例是有争议的，因为一系列标记物用于识别TcB，但几乎没有共识。为了阐明TdR在RA中的地位，我们调查了TdR的比例，重点是它们的定义。我们使用PubMed和Google Scholar确定了报告类风湿关节炎患者中TdR比例的研究。我们进行了一项系统回顾和荟萃分析，以评估RA患者和对照组外周血（PB）和滑液（SF）中CD 4 + T细胞中TcB（FOXP 3阳性和/或CD 25阳性）的比例。共选择了31项研究。RA患者和对照组外周血T淋巴细胞在CD 4 + T细胞中的比例无显著性差异（-0.65，[-1.30，0.01]）。然后，我们根据个人定义进行了子分析。由CD 25或FOXP 3单独定义的T细胞比例在RA患者和对照受试者之间没有差异。由FOXP 3和CD 25定义的TcB在RA患者中的比例低于对照组（-2.42 [-3.49，-1.34]）。在RA患者中，SF中FOXP 3和CD 25定义的T细胞比例高于PB（3.27 [0.40，6.14]）。Tregs的状态根据定义系统而有所不同。在RA患者中，通过更严格和功能验证的方法定义的T细胞比例在PB中下降，在SF中增加。如果类风湿关节炎中TdR的比例不同，则需要准确和功能相关的TdR定义来阐明其在类风湿关节炎中的地位。
Regulatory T cells (Tregs) have important functions in peripheral immune tolerance. Dysfunction of Tregs is considered to be a pivotal cause of autoimmune diseases, including rheumatoid arthritis (RA). However, previous reports describing the proportion of Tregs among CD4+ T cells in RA patients were controversial because a range of markers are used to identify Tregs with little consensus. To clarify the status of Tregs in RA, we investigated the proportion of Tregs with focusing on the definitions of them. We identified the studies reporting the proportion of Tregs in RA patients using PubMed and Google Scholar. We performed a systematic review of them and a meta-analysis to evaluate the proportion of Tregs (FOXP3-positive and/or CD25-positive) among CD4+ T cells in peripheral blood (PB) and synovial fluid (SF) of RA patients and control subjects. A total 31 studies were selected. The proportion of Tregs defined by all definitions among CD4+ T cells in PB was not significantly different between RA patients and control subjects (-0.65, [-1.30, 0.01]). Then we performed sub-analyses based on individual definitions. The proportion of Tregs defined by either CD25 or FOXP3 alone did not differ between RA patients and control subjects. The proportion of Tregs defined by both FOXP3 and CD25 was lower in RA patients than that in control subjects (-2.42 [-3.49, -1.34]). The proportion of Tregs defined by both FOXP3 and CD25 was higher in SF than that in PB among RA patients (3.27 [0.40, 6.14]). The status of Tregs varied according to the definition system. The proportion of Tregs defined by stricter and functionally validated methods decreased in PB and increased in SF among RA patients. If the proportion of Tregs differs in RA, accurate and functionally relevant definitions of Tregs are necessary to elucidate their status in RA.
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