The adventitia: essential regulator of vascular wall structure and function.
The adventitia: essential regulator of vascular wall structure and function.
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DOI：
10.1146/annurev-physiol-030212-183802
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发表时间：
2013
影响因子：
18.2
通讯作者：
Frid MG
中科院分区：
文献类型：
--
作者：
Stenmark KR;Yeager ME;El Kasmi KC;Nozik-Grayck E;Gerasimovskaya EV;Li M;Riddle SR;Frid MG
血管外膜是检索、整合、储存和释放管壁功能关键调节因子的生物处理中心。它是血管壁中最复杂的隔室，由多种细胞组成，包括成纤维细胞、免疫调节细胞(树突状细胞和巨噬细胞)、前体细胞、血管内皮细胞和周细胞以及肾上腺素能神经。作为对血管应激或损伤的反应，驻留的外膜细胞通常首先被激活和重新编程，然后影响血管壁的张力和结构，启动和持续慢性血管炎症，并刺激血管扩张，这可以作为持续炎症和祖细胞输送到血管壁的管道。本文综述了目前的证据表明，外膜从外到内是调节血管壁功能和结构的关键因素。
The vascular adventitia acts as a biological processing center for the retrieval, integration, storage, and release of key regulators of vessel wall function. It is the most complex compartment of the vessel wall and is comprised of a variety of cells including fibroblasts, immunomodulatory cells (dendritic and macrophages), progenitor cells, vasa vasorum endothelial cells and pericytes, and adrenergic nerves. In response to vascular stress or injury, resident adventitial cells are often the first to be activated and re-programmed to then influence tone and structure of the vessel wall, to initiate and perpetuate chronic vascular inflammation, and to act to stimulate expansion of the vasa vasorum, which can act as a conduit for continued inflammatory and progenitor cell delivery to the vessel wall. This review presents the current evidence demonstrating that the adventitia acts as a key regulator of vascular wall function and structure from the “outside-in.”
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DOI：
10.1016/j.bbamcr.2008.10.004
发表时间：
2009-05
期刊：
Biochimica et biophysica acta
影响因子：
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作者：
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