IUPHAR-DB: updated database content and new features.
IUPHAR-DB: updated database content and new features.
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DOI：
10.1093/nar/gks960
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发表时间：
2013-01
影响因子：
14.9
通讯作者：
NC-IUPHAR
中科院分区：
文献类型：
--
作者：
Sharman JL;Benson HE;Pawson AJ;Lukito V;Mpamhanga CP;Bombail V;Davenport AP;Peters JA;Spedding M;Harmar AJ;NC-IUPHAR
国际基础和临床药理学联合会（IUPHAR）数据库IUPHAR-DB（http：www.iuphar-db.org）是一个开放访问的在线数据库，提供关于人类和啮齿动物受体和其他药物靶点以及作用于它们的物质的主要文献的详细、专家驱动的注释。目前发布的信息包括来自四个主要蛋白质类别（G蛋白偶联受体，核激素受体，电压和配体门控离子通道）的646个基因的产物和与它们相互作用的生物活性分子（内源性配体，许可药物和关键药理学工具）。我们之前已经描述了数据库中小分子配体数据的分类和管理;在本次更新中，我们注释了366种内源性肽配体及其氨基酸序列，翻译后修饰，与前体基因的链接，物种差异以及与数据库中其他分子的关系（例如，来自相同前体的分子）。我们还将靶点与其内源性配体（肽和小分子）相匹配，特别注意识别由前体蛋白的翻译后修饰产生的生物活性肽配体。对数据库的其他改进包括加强了数据库中靶点和配体临床相关性的信息，与其他数据库的链接更广泛，以及一个将酶作为药物靶点的试点项目。
The International Union of Basic and Clinical Pharmacology (IUPHAR) database, IUPHAR-DB (http://www.iuphar-db.org) is an open access, online database providing detailed, expert-driven annotation of the primary literature on human and rodent receptors and other drug targets, together with the substances that act on them. The present release includes information on the products of 646 genes from four major protein classes (G protein-coupled receptors, nuclear hormone receptors, voltage- and ligand-gated ion channels) and ∼3180 bioactive molecules (endogenous ligands, licensed drugs and key pharmacological tools) that interact with them. We have described previously the classification and curation of data for small molecule ligands in the database; in this update we have annotated 366 endogenous peptide ligands with their amino acid sequences, post-translational modifications, links to precursor genes, species differences and relationships with other molecules in the database (e.g. those derived from the same precursor). We have also matched targets with their endogenous ligands (peptides and small molecules), with particular attention paid to identifying bioactive peptide ligands generated by post-translational modification of precursor proteins. Other improvements to the database include enhanced information on the clinical relevance of targets and ligands in the database, more extensive links to other databases and a pilot project for the curation of enzymes as drug targets.
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影响因子：
14.9
作者：
Wishart DS;Knox C;Guo AC;Eisner R;Young N;Gautam B;Hau DD;Psychogios N;Dong E;Bouatra S;Mandal R;Sinelnikov I;Xia J;Jia L;Cruz JA;Lim E;Sobsey CA;Shrivastava S;Huang P;Liu P;Fang L;Peng J;Fradette R;Cheng D;Tzur D;Clements M;Lewis A;De Souza A;Zuniga A;Dawe M;Xiong Y;Clive D;Greiner R;Nazyrova A;Shaykhutdinov R;Li L;Vogel HJ;Forsythe I
通讯作者：
Forsythe I
影响因子：
14.9
作者：
Kanehisa M;Goto S;Sato Y;Furumichi M;Tanabe M
通讯作者：
Tanabe M
影响因子：
14.9
作者：
Hunter S;Jones P;Mitchell A;Apweiler R;Attwood TK;Bateman A;Bernard T;Binns D;Bork P;Burge S;de Castro E;Coggill P;Corbett M;Das U;Daugherty L;Duquenne L;Finn RD;Fraser M;Gough J;Haft D;Hulo N;Kahn D;Kelly E;Letunic I;Lonsdale D;Lopez R;Madera M;Maslen J;McAnulla C;McDowall J;McMenamin C;Mi H;Mutowo-Muellenet P;Mulder N;Natale D;Orengo C;Pesseat S;Punta M;Quinn AF;Rivoire C;Sangrador-Vegas A;Selengut JD;Sigrist CJ;Scheremetjew M;Tate J;Thimmajanarthanan M;Thomas PD;Wu CH;Yeats C;Yong SY
通讯作者：
Yong SY
影响因子：
14.9
作者：
Harmar AJ;Hills RA;Rosser EM;Jones M;Buneman OP;Dunbar DR;Greenhill SD;Hale VA;Sharman JL;Bonner TI;Catterall WA;Davenport AP;Delagrange P;Dollery CT;Foord SM;Gutman GA;Laudet V;Neubig RR;Ohlstein EH;Olsen RW;Peters J;Pin JP;Ruffolo RR;Searls DB;Wright MW;Spedding M
通讯作者：
Spedding M
影响因子：
3.9
作者：
Amberger, Joanna;Bocchini, Carol;Hamosh, Ada
通讯作者：
Hamosh, Ada