Association between carotid plaque composition assessed by multidetector computed tomography and cerebral embolism after carotid stenting
Association between carotid plaque composition assessed by multidetector computed tomography and cerebral embolism after carotid stenting
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多探测器计算机断层扫描评估颈动脉斑块成分与颈动脉支架置入术后脑栓塞之间的关联
DOI：
10.1007/s00234-011-0920-9
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发表时间：
2012
期刊：
影响因子：
2.8
通讯作者：
Jun-ichiro Hamada
中科院分区：
文献类型：
--
作者：
Naoyuki Uchiyama;Koichi Misaki;Masanao Mohri;Takuya Watanabe;Yuichi Hirota;Mitsutoshi Nakada;Yutaka Hayashi;Fumiaki Ueda;Jun-ichiro Hamada
目的探讨颈动脉支架置入术(CAS)后多层螺旋CT(MDCT)分析颈动脉斑块成分与弥散加权成像(DWI)发现的新的缺血性病变之间的关系。方法对19例CAS患者行颈动脉支架置入术前，应用多层螺旋CT(MDCT)对颈动脉斑块特征进行定量和定性分析。Hounsfield单位(HU)值为<；0、0-60、60-130和>；600的颈动脉斑块被方便地细分为四个部分。用弥散加权成像评价远端血栓的发生率。皮尔逊相关分析评估斑块成分与脑血栓发生率之间的关系。结果15例患者(79%)在CAS术后发现新的弥散加权成像病变。高信号 ~ 表现如下：6例中有1例，5例中2例为 ~ 5，2例中2例为6，10例中有2例。HU <； 0、0-60、60-130和>；600斑块成分的平均体积分别为5.4mm3、200mm3、260mm3和59mm3。同侧高信号弥散加权像病灶数目与HU <； 0斑块体积呈正相关(r= 0.927；P<； 0.0001)。高信号斑块数目与HU 0.568~60斑块体积(r= 0.609；P= 0.0099)、HU <； 0与HU 0~60总和(r= 0.609；P= 0.0047)呈中度相关。
IntroductionWe aimed to assess the relationship between atherosclerotic carotid plaque composition analyzed using multidetector computed tomography (MDCT) and the appearance of new ischemic lesions detected by diffusion-weighted images (DWI) after carotid artery stenting (CAS).MethodsWe quantitatively and qualitatively analyzed plaque characteristics in carotid arteries using MDCT before CAS in 19 patients. Carotid plaques were expediently subdivided into four components with Hounsfield unit (HU) values of <0, 0–60, 60–130, and >600. The incidence of distal embolism was evaluated with DWI. Pearson's correlation analyses were used to assess the association between plaque composition and the incidence of cerebral embolization.ResultsFifteen patients (79%) demonstrated new DWI lesions after CAS. High-signal DWIs were noted as follows: one in six patients, 2 ~ 5 in five patients, 6 ~ 10 in two patients, and >10 in two patients. The mean volumes of the plaque components for HU < 0, 0–60, 60–130, and >600 were 5.4, 200, 260, and 59 mm3, respectively. There was a strong correlation between the number of high-signal DWI lesions in the ipsilateral side and the plaque volume of HU < 0 (r= 0.927;P< 0.0001). There was a moderate correlation between the number of high-signal DWI lesions and the plaque volume of HU 0–60 (r= 0.568;P= 0.0099) and the sum total of HU < 0 and HU 0–60 (r= 0.609;P= 0.0047).ConclusionsQuantitative and qualitative tissue characterization of carotid plaques using MDCT might be a useful predictor for silent ischemic lesions after CAS.
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影响因子：
37.8
作者：
Biasi, GM;Froio, A;Valsecchi, MG
通讯作者：
Valsecchi, MG
影响因子：
4.3
作者：
Rapp, Joseph H.;Wakil, Laura;Wintermark, Max
通讯作者：
Wintermark, Max
影响因子：
5.9
作者：
de Weert, TT;Ouhlous, M;van der Lugt, A
通讯作者：
van der Lugt, A
DOI：
10.1161/01.atv.8.2.103
发表时间：
1988-03-01
期刊：
ARTERIOSCLEROSIS
影响因子：
--
作者：
SMALL, DM
通讯作者：
SMALL, DM
影响因子：
4.3
作者：
Timaran, Carlos H.;Rosero, Eric B.;Clagett, G. Patrick
通讯作者：
Clagett, G. Patrick