Monitoring cardiac fibrosis: a technical challenge.

Monitoring cardiac fibrosis: a technical challenge.
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DOI:
10.1007/s12471-011-0226-x
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发表时间:
2012-01
影响因子:
2
通讯作者:
van Rijen, H. V. M.
van Rijen, H. V. M.
中科院分区:
医学4区
文献类型:
--
作者:
de Jong, S.;van Veen, T. A. B.;de Bakker, J. M. T.;van Rijen, H. V. M.

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心脏含有胶原蛋白网络,有助于心脏的收缩性并提供心脏力量。在心脏疾病中,经常观察到胶原沉积的增加。这种纤维化形成引起收缩和舒张功能障碍,并在致心律失常底物中起主要作用。因此,准确检测心脏纤维化及其进展对于心脏病患者的诊断和治疗具有重要的临床意义。为了评估心脏胶原沉积,使用了侵入性和非侵入性技术。在这篇综述中,总结了目前在临床和实验环境中使用的不同技术,并讨论了这些技术的优点和缺点。
The heart contains a collagen network that contributes to the contractility of the heart and provides cardiac strength. In cardiac diseases, an increase in collagen deposition is often observed. This fibrosis formation causes systolic and diastolic dysfunction, and plays a major role in the arrythmogenic substrate. Therefore, accurate detection of cardiac fibrosis and its progression is of clinical importance with regard to diagnostics and therapy for patients with cardiac disease. To evaluate cardiac collagen deposition, both invasive and non-invasive techniques are used. In this review the different techniques that are currently used in clinical and experimental setting are summarised, and the advantages and disadvantages of these techniques are discussed.
DOI: 10.1111/j.1749-6632.1995.tb17438.x
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