The clinicopathologic association of c-MET overexpression in Iranian gastric carcinomas; an immunohistochemical study of tissue microarrays.
The clinicopathologic association of c-MET overexpression in Iranian gastric carcinomas; an immunohistochemical study of tissue microarrays.
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DOI：
10.1186/1746-1596-7-57
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发表时间：
2012-05-28
影响因子：
2.6
通讯作者：
Kalantary E
中科院分区：
文献类型：
--
作者：
Sotoudeh K;Hashemi F;Madjd Z;Sadeghipour A;Molanaei S;Kalantary E
C-Met是一种癌基因蛋白，在胃癌发生中起重要作用，已被认为是一种预后标志物和潜在的治疗靶点。本研究的目的是利用组织芯片技术评估c-met基因在伊朗人胃癌中的过表达频率及其与临床病理变量的关系。在一项横断面研究中，收集了德黑兰-伊朗两所大学医院2008年至2009年2 期间接受根治性胃切除术的130例胃癌患者的代表性石蜡切片，并用免疫组织化学方法研究了c-met的表达。男99例，女25例，平均年龄61.5 。71.0%(88/124)的肿瘤有c-met高表达。C-MET高表达与肠道肿瘤类型(P = 0.04)、肿瘤侵袭深度、Pt3和Pt4与Pt1和Pt2相比(P = 0.014)、神经侵犯(P = 0.002)和晚期TNM分期、3和4期与1和2期(P = 0.044)有关。C-Met的高表达与年龄、性别、肿瘤部位、分化程度和远处转移无关，但与淋巴结转移(P = 0.065)和血管侵犯(P = 0.078)有关。C-met癌基因蛋白在伊朗胃癌中呈高表达，并与肿瘤类型、侵袭深度、神经侵袭、TNM分期等临床病理特征有关。它还可以支持c-met是伊朗胃癌靶向治疗的潜在标记物的想法。本文的虚拟幻灯片(S)可在此处找到：http://www.diagnosticpathology.diagnomx.eu/vs/9744598757151429
c-MET is an oncogene protein that plays important role in gastric carcinogenesis and has been introduced as a prognostic marker and potential therapeutic target. The aim of this study was to evaluate the frequency of c-MET overexpression and its relationship with clinicopathological variables in gastric cancer of Iranian population using tissue microarray. In a cross sectional study, representative paraffin blocks of 130 patients with gastric carcinoma treated by curative gastrectomy during a 2 years period of 2008–2009 in two university hospitals in Tehran-Iran were collected in tissue microarray and c-MET expression was studied by immunohistochemical staining. Finally 124 cases were evaluated, constituted of 99 male and 25 female with the average age of 61.5 years. In 71% (88/124) of tumors, c-MET high expression was found. c-MET high expression was more associated with intestinal than diffuse tumor type (P = 0.04), deeper tumor invasion, pT3 and pT4 versus pT1 and pT2 (P = 0.014), neural invasion (P = 0.002) and advanced TNM staging, stage 3 and 4 versus stage 1 and2 (P = 0.044). The c-MET high expression was not associated with age, sex, tumor location, differentiation grade and distant metastasis, but relative associations with lymph node metastasis (P = 0.065) and vascular invasion (P = 0.078) were observed. c-MET oncogene protein was frequently overexpressed in Iranian gastric carcinomas and it was related to clinicopathological characteristics such as tumor type, depth of invasion, neural invasion and TNM staging. It can also support the idea that c-MET is a potential marker for target therapy in Iranian gastric cancer. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9744598757151429
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影响因子：
30.8
作者：
Schmidt, L;Duh, FM;Zbar, B
通讯作者：
Zbar, B
影响因子：
4.6
作者：
McIntire, Maria;Redston, Mark
通讯作者：
Redston, Mark
DOI：
10.1111/apm.1965.64.1.31
发表时间：
1965-01-01
期刊：
ACTA PATHOLOGICA ET MICROBIOLOGICA SCANDINAVICA
影响因子：
--
作者：
LAUREN, P
通讯作者：
LAUREN, P
影响因子：
9.6
作者：
Mullaney, PJ;Wadley, MS;Fielding, JWL
通讯作者：
Fielding, JWL
影响因子：
4.2
作者：
Lee, Jeeyun;Seo, Jin Won;Park, Joon Oh
通讯作者：
Park, Joon Oh