The effects of cognitive behavioral therapy on resting-state functional brain network in drug-naive patients with obsessive-compulsive disorder.
The effects of cognitive behavioral therapy on resting-state functional brain network in drug-naive patients with obsessive-compulsive disorder.
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DOI：
10.1002/brb3.963
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发表时间：
2018-05
影响因子：
3.1
通讯作者：
Li Z
中科院分区：
文献类型：
--
作者：
Li P;Yang X;Greenshaw AJ;Li S;Luo J;Han H;Liu J;Zhong Z;Guo Z;Xiong H;Yao S;Chen Y;Sun J;Li Z
虽然认知行为疗法(CBT)是治疗强迫症(OCD)的一种有效方法，但其治疗机制尚不清楚。本研究旨在探讨CBT对强迫症患者内在全脑功能网络改变的影响。对20例未服药和未合并药物的强迫症患者在CBT治疗前和治疗12周后进行静息状态功能磁共振成像。此外，对20名健康对照进行了两次扫描，扫描间隔为12周。采用图论度中心度(DC)方法和功能连通性方法分析强迫症患者CBT治疗前后全脑功能网络中枢和连通性的变化。左侧背外侧前额叶皮质(DLPFC)的DC存在明显的×1次交互作用；CBT治疗后，左侧DLPFC的DC显著减少。强迫症患者左侧DLPFC与右侧眶前皮质之间的静息状态功能连接性(RSFC)在基线时增加，经CBT治疗后恢复正常。强迫症患者左侧DLPFC与默认模式网络(DMN)之间RSFC的变化与临床症状的变化呈正相关。这些发现表明，CBT可以调节强迫症患者皮质-纹状体-丘脑-皮质回路中固有功能网络中枢的变化。认知控制网络和DMN连接可能是评价CBT治疗强迫症的一个潜在的成像生物标志物。
Although cognitive behavioral therapy (CBT) is an effective treatment for obsessive–compulsive disorder (OCD), the treatment mechanisms remain poorly understood. This study aimed to investigate the effects of CBT on changes in the intrinsic whole‐brain functional network of OCD patients. Twenty drug‐naive and noncomorbid OCD patients were recruited, and resting‐state functional magnetic resonance imaging was performed before and after 12 weeks of CBT. Moreover, 20 healthy controls were scanned twice with a 12‐week interval. A graph‐theory degree centrality (DC) approach and functional connectivity method were used to analyze the whole‐brain functional network hub and connectivity changes in OCD patients before and after CBT treatment. A significant group × time interaction on DC was found in the left dorsolateral prefrontal cortex (DLPFC); the DC in the left DLPFC was significantly reduced after CBT treatment. Resting‐state functional connectivity (RSFC) between the left DLPFC and right orbitofrontal cortex was increased in the OCD patients at baseline, and normalized after CBT treatment. RSFC changes between the left DLPFC and default mode network (DMN) positively correlated with changes in clinical symptoms in OCD patients. These findings suggest that CBT can modulate changes in intrinsic functional network hubs in the cortico–striato–thalamo‐cortical circuit in OCD patients. Cognitive control network and DMN connectivity may be a potential imaging biomarker for evaluating CBT treatment for OCD.
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影响因子：
6.9
作者：
Olatunji, B. O.;Ferreira-Garcia, R.;Mataix-Cols, D.
通讯作者：
Mataix-Cols, D.
影响因子：
25.8
作者：
Beucke, Jan C.;Sepulcre, Jorge;Kathmann, Norbert
通讯作者：
Kathmann, Norbert
影响因子：
10.5
作者：
Beucke, Jan C.;Sepulcre, Jorge;Kaufmann, Christian
通讯作者：
Kaufmann, Christian
影响因子：
2.6
作者：
Goettlich, Martin;Kraemer, Ulrike M.;Zurowski, Bartosz
通讯作者：
Zurowski, Bartosz
影响因子：
25
作者：
Kriegeskorte, Nikolaus;Simmons, W. Kyle;Bellgowan, Patrick S. F.;Baker, Chris I.
通讯作者：
Baker, Chris I.