Boron supplementation and activated factor VII in healthy men
Boron supplementation and activated factor VII in healthy men
复制标题
健康男性的硼补充剂和活化的 VII 因子
DOI：
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发表时间：
2002
影响因子：
4.7
通讯作者：
J. Strain
中科院分区：
文献类型：
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作者：
J. Wallace;M. Hannon;P. Robson;WS Gilmore;SA Hubbard;J. Strain
目的：本研究的目的是确定是否餐后浓度的丝氨酸蛋白酶凝血因子VII（VIIa）的活性成分降低急性硼补充invivo.Design：一个急性，随机，安慰剂对照，双盲，cross-over study.Setting：自由生活population.Subjects：15个明显健康的男性，年龄45-65 y.Interventions：Subjects访问了中心的两个场合，与研究日分开最少2周。采集空腹血样后，受试者接受安慰剂或11.6 mg硼（以102.6 mg十水四硼酸钠形式给药）急性推注以及标准富脂餐。 在试验餐给药后1、2、4和6 h采集血样，在此期间受试者可自由饮用去离子水。分析血液样本中胰岛素、葡萄糖、脂质和硼的浓度。测定活化因子VIIa和因子VII抗原的浓度，以及凝血因子VII、IX和X的活性。结果：与安慰剂相比，补充硼后血浆硼浓度显著升高（0.124±0.02 vs 0.008±0.01 mg/l; P≤0.001）。 急性硼补充对血浆胰岛素和葡萄糖浓度或血脂或凝血因子谱没有显着影响。高脂餐后凝血因子VIIa显著升高（1.05±0.07 vs 1.26±0.07; P≤0.001），但补充硼并没有改变这种升高。结论：本研究的结果表明，急性补充硼（11.6 mg硼）不会改变高脂餐后凝血因子VIIa的活性。
Objective: The aim of the present study was to determine whether postprandial concentrations of the active component of serine protease coagulation factor VII (VIIa) were lowered by acute boron supplementation in vivo.Design: An acute, randomized, placebo-controlled, double blind, cross-over study.Setting: Free-living population.Subjects: Fifteen apparently healthy men, aged 45–65 y.Interventions: Subjects visited the centre on two occasions, with the study days separated by a minimum of 2 weeks. Following collection of a fasting blood sample, subjects received either placebo or acute bolus of 11.6 mg boron (given as 102.6 mg sodium tetraborate decahydrate) together with a standard fat-rich meal. Blood samples were obtained at 1, 2, 4 and 6 h after the administration of the test meal, during which time subjects were at liberty to consume deionized water only. Blood samples were assayed for concentrations of insulin, glucose, lipids and boron. Measurement of the concentration of activated factor VIIa and of factor VII antigen, and of the activity of coagulation factors VII, IX and X was also carried out.Results: Plasma boron concentrations were significantly higher following consumption of the boron supplement compared with placebo (0.124±0.02 vs 0.008±0.01 mg/l; P≤0.001). There was no significant effect of acute boron supplementation on plasma insulin and glucose concentration or on blood lipid or coagulation factor profile. Factor VIIa rose significantly following consumption of the high fat meal (1.05±0.07 vs 1.26±0.07; P≤0.001), but this increase was not altered by boron supplementation.Conclusions: Results from this study suggest that acute boron supplementation (at 11.6 mg boron) does not alter the activity of factor VIIa following consumption of a high-fat meal.Sponsorship: This work was funded by Borax Europe Ltd.
影响因子：
8.7
作者：
Feng, DL;Tofler, GH;Lindpaintner, K
通讯作者：
Lindpaintner, K