Insulin‐like growth factor‐2 antisense oligonucleotides inhibits myopia by expression blocking of retinal insulin‐like growth factor‐2 in guinea pig

Insulin‐like growth factor‐2 antisense oligonucleotides inhibits myopia by expression blocking of retinal insulin‐like growth factor‐2 in guinea pig
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胰岛素样生长因子2反义寡核苷酸通过阻断豚鼠视网膜胰岛素样生长因子2的表达抑制近视

DOI:
10.1111/j.1442-9071.2011.02683.x
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发表时间:
2012
影响因子:
4
通讯作者:
Wei
Wei
中科院分区:
医学2区
文献类型:
--
作者:
Renhong Tang;Jia Tan;Zhi;Shaozhen Zhao;Ying;Wei

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目的:为明确胰岛素样生长因子2(IGF - 2)在近视发生发展中的作用,本研究对形觉剥夺(FD)眼视网膜中IGF - 2的动态表达进行了检测,并观察玻璃体内注射IGF - 2反义寡核苷酸(ASON)对FD眼屈光度及眼轴长度的影响。
Objective:  To clarify the role of IGF‐2 on the development of myopia, the dynamic expression of IGF‐2 was investigated in the FD eyes’ retina, and the effects of intravitreous injection with IGF‐2 ASON was studied on the diopter and axial eye length of FD eyes.
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期刊: SCIENCE
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