Association between Fat-Free Mass and Brain Size in Extremely Preterm Infants.
Association between Fat-Free Mass and Brain Size in Extremely Preterm Infants.
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DOI：
10.3390/nu13124205
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发表时间：
2021-11-24
期刊：
影响因子：
5.9
通讯作者：
Goeral K
中科院分区：
文献类型：
--
作者：
Binder C;Buchmayer J;Thajer A;Giordano V;Schmidbauer V;Harreiter K;Klebermass-Schrehof K;Berger A;Goeral K
产后生长受限和去脂体重缺陷与神经发育受损有关。支持正常大脑生长和发育的最佳身体成分仍不清楚。这项研究调查了早产儿的身体成分和大脑大小之间的关系。我们纳入了 2017 年至 2021 年间出生的 118 名妊娠 <28 周的婴儿，他们在足月相当年龄时接受了身体成分（去脂体重 (FFM) 和脂肪质量 (FM)）和脑磁共振成像，以量化大脑大小（大脑双顶直径 (cBPD)、骨双顶直径 (bBPD)、半球间距离 (IHD)、小脑横径 (tCD)）。 FFM Z 得分与较高的 cBPD Z 得分（rs = 0.69；p < 0.001）、bBPD Z 得分（rs = 0.48；p < 0.001）和 tCD Z 得分（rs = 0.30；p = 0.002）显着相关； FM Z 得分与较小的大脑尺寸显着相关（cBPD Z 得分（rs = -0.32；p < 0.001）和 bBPD Z 得分（rs = -0.42；p < 0.001）。相比之下，体重（rs = 0.08）、长度（rs = -0.01）和头围 Z 得分（rs = 0.14）则不然。根据重要的新生儿变量调整的线性回归模型显示FFM Z 分数与较高的 cBPD Z 分数（中位数 0.50，95% CI：0.59，0.43；p < 0.001）和 bBPD Z 分数（中位数 0.31，95% CI：0.42，0.19；p < 0.001）独立且显着相关；FM Z 分数与较低的 cBPD 独立且显着相关Z 分数（中位数 -0.27，95% CI：-0.42，-0.11；p < 0.001）和 bBPD Z 分数（中位数 -0.32，95% CI：-0.45，-0.18；p < 0.001）。较高的 FFM Z 分数和较低的 FM Z 分数与足月相当年龄的大脑尺寸显着相关。表明早期身体成分可能是评估并最终优化大脑生长和神经发育的有用工具。
Postnatal growth restriction and deficits in fat-free mass are associated with impaired neurodevelopment. The optimal body composition to support normal brain growth and development remains unclear. This study investigated the association between body composition and brain size in preterm infants. We included 118 infants born <28 weeks of gestation between 2017–2021, who underwent body composition (fat-free mass (FFM) and fat mass (FM)) and cerebral magnetic resonance imaging to quantify brain size (cerebral biparietal diameter (cBPD), bone biparietal diameter (bBPD), interhemispheric distance (IHD), transverse cerebellar diameter (tCD)) at term-equivalent age. FFM Z-Score significantly correlated with higher cBPD Z-Score (rs = 0.69; p < 0.001), bBPD Z-Score (rs = 0.48; p < 0.001) and tCD Z-Score (rs = 0.30; p = 0.002); FM Z-Score significantly correlated with lower brain size (cBPD Z-Score (rs = −0.32; p < 0.001) and bBPD Z-Score (rs = −0.42; p < 0.001). In contrast weight (rs = 0.08), length (rs = −0.01) and head circumference Z-Score (rs = 0.14) did not. Linear regression model adjusted for important neonatal variables revealed that FFM Z-Score was independently and significantly associated with higher cBPD Z-Score (median 0.50, 95% CI: 0.59, 0.43; p < 0.001) and bBPD Z-Score (median 0.31, 95% CI: 0.42, 0.19; p < 0.001); FM Z-Score was independently and significantly associated with lower cBPD Z-Score (median −0.27, 95% CI: −0.42, −0.11; p < 0.001) and bBPD Z-Score (median −0.32, 95% CI: −0.45, −0.18; p < 0.001). Higher FFM Z-Score and lower FM Z-scores were significantly associated with larger brain size at term-equivalent age. These results indicate that early body composition might be a useful tool to evaluate and eventually optimize brain growth and neurodevelopment.
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DOI：
10.3174/ajnr.a1309
发表时间：
2009-01
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Nguyen The Tich S;Anderson PJ;Shimony JS;Hunt RW;Doyle LW;Inder TE
通讯作者：
Inder TE
影响因子：
2.5
作者：
Mercier, Charles E.;Dunn, Michael S.;Soll, Roger F.
通讯作者：
Soll, Roger F.
影响因子：
5.1
作者：
Ramel, Sara E.;Gray, Heather L.;Demerath, Ellen W.
通讯作者：
Demerath, Ellen W.
影响因子：
5.9
作者：
Ramel, Sara E.;Haapala, Jacob;Demerath, Ellen W.
通讯作者：
Demerath, Ellen W.
影响因子：
8
作者：
Cheong, Jeanie L. Y.;Hunt, Rod W.;Doyle, Lex W.
通讯作者：
Doyle, Lex W.