Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants.
Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants.
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DOI：
10.1371/journal.pone.0241824
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Pell JP
中科院分区：
文献类型：
--
作者：
Ho FK;Petermann-Rocha F;Gray SR;Jani BD;Katikireddi SV;Niedzwiedz CL;Foster H;Hastie CE;Mackay DF;Gill JMR;O'Donnell C;Welsh P;Mair F;Sattar N;Celis-Morales CA;Pell JP
据报道，老年人患COVID-19死亡率的风险更高。本研究探讨了介导这种关联的因素，以及在没有其他危险因素的情况下，老年是否与死亡风险增加相关。在英国生物银行（UK Biobank）的一项人群队列研究中，基线数据与COVID-19死亡相关。Poisson回归用于研究当前年龄与COVID-19死亡率之间的关联。合资格参与者中，438名（0. 09%）死于COVID-19。当前年龄与COVID-19死亡率呈指数相关。总体而言，年龄≥75岁的受试者死亡风险是<65岁受试者的13倍（95%CI 9.13-17.85）。1秒用力呼气量低、收缩压高、握力低和多种长期疾病是重要的介导因素，共同解释了39.3%的过度风险。这些风险因素与COVID-19死亡率之间的关联在老年参与者中更强。与所有年龄<65岁的参与者相比，年龄≥75岁且无其他风险因素的参与者的风险为4倍（95% CI 1.57-9.96，P = 0.004）。其他风险因素可以部分解释老年人中较高的COVID-19死亡率。“健康”的老年人的风险要低得多。尽管如此，年龄较大是COVID-19死亡率的独立风险因素。
Older people have been reported to be at higher risk of COVID-19 mortality. This study explored the factors mediating this association and whether older age was associated with increased mortality risk in the absence of other risk factors. In UK Biobank, a population cohort study, baseline data were linked to COVID-19 deaths. Poisson regression was used to study the association between current age and COVID-19 mortality. Among eligible participants, 438 (0.09%) died of COVID-19. Current age was associated exponentially with COVID-19 mortality. Overall, participants aged ≥75 years were at 13-fold (95% CI 9.13–17.85) mortality risk compared with those <65 years. Low forced expiratory volume in 1 second, high systolic blood pressure, low handgrip strength, and multiple long-term conditions were significant mediators, and collectively explained 39.3% of their excess risk. The associations between these risk factors and COVID-19 mortality were stronger among older participants. Participants aged ≥75 without additional risk factors were at 4-fold risk (95% CI 1.57–9.96, P = 0.004) compared with all participants aged <65 years. Higher COVID-19 mortality among older adults was partially explained by other risk factors. ‘Healthy’ older adults were at much lower risk. Nonetheless, older age was an independent risk factor for COVID-19 mortality.
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DOI：
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发表时间：
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期刊：
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