HLA-DRB1 alleles are associated with the susceptibility to sporadic Parkinson's disease in Chinese Han population.
HLA-DRB1 alleles are associated with the susceptibility to sporadic Parkinson's disease in Chinese Han population.
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DOI：
10.1371/journal.pone.0048594
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Xu P
中科院分区：
文献类型：
--
作者：
Sun C;Wei L;Luo F;Li Y;Li J;Zhu F;Kang P;Xu R;Xiao L;Liu Z;Xu P
免疫紊乱可能在帕金森病（PD）的发病机制中发挥重要作用。最近，HLA-DR 区域的多态性被发现与欧洲血统人群中的散发性 PD 相关。然而，HLA 复合体的多态性因种族和地理起源而存在很大差异。为了探讨中国汉族人群中 HLA-DR 区多态性与散发性 PD 之间的关系，我们采用聚合酶链式反应序列分型 (PCR-SBT) 对两个独立系列中的 567 名散发性 PD 患者和 746 名健康对照者进行了 HLA-DRB1 基因座的基因分型。 χ2检验用于评估患者和健康对照之间等位基因频率的分布。通过无条件逻辑回归估计 HLA-DRB1 等位基因对 PD 风险的影响。我们发现散发性 PD 患者中 HLA-DRB1*0301 的出现频率显着高于健康对照，并且 HLA-DRB1*0301 与 PD 风险之间存在正相关性（与发病年龄无关）。相反，散发性帕金森病患者的 HLA-DRB1*0406 频率低于健康对照，HLA-DRB1*0406 与帕金森病风险呈负相关。此外，我们对195205名个体进行荟萃分析，总结了这两个等位基因在不同种族地区人群中的频率，我们发现欧洲血统人群中HLA-DRB1*0301的频率较高，但HLA-DRB1*0406的频率低于亚洲人，这与欧洲血统人群中散发性PD的较高患病率一致。基于这些结果，我们推测HLA-DRB1等位基因与中国汉族人群散发性PD的易感性相关，其中HLA-DRB1*0301是风险等位基因，而HLA-DRB1*0406的作用值得争论。
Immune disorders may play an important role in the pathogenesis of Parkinson's disease (PD). Recently, polymorphisms in the HLA-DR region have been found to be associated with sporadic PD in European ancestry populations. However, polymorphisms in the HLA complex are highly variable with ethnic and geographic origin. To explore the relationships between polymorphisms of the HLA-DR region and sporadic PD in Chinese Han population, we genotyped 567 sporadic PD patients and 746 healthy controls in two independent series for the HLA-DRB1 locus with Polymerase chain reaction-sequence based typing(PCR-SBT). The χ2 test was used to evaluate the distribution of allele frequencies between the patients and healthy controls. The impact of HLA-DRB1 alleles on PD risk was estimated by unconditional logistic regression. We found a significant higher frequency of HLA-DRB1*0301 in sporadic PD patients than in healthy controls and a positive association, which was independent of onset age, between HLA-DRB1*0301 and PD risk. Conversely, a lower frequency of HLA-DRB1*0406 was found in sporadic PD patients than in healthy controls, with a negative association between HLA-DRB1*0406 and PD risk. Furthermore, a meta-analysis involving 195205 individuals was conducted to summarize the frequencies of these two alleles in populations from various ethnic regions, we found a higher frequency of HLA-DRB1*0301, but a lower frequency of HLA-DRB1*0406 in European ancestry populations than that in Asians, this was consistent with the higher prevalence of sporadic PD in European ancestry populations. Based on these results, we speculate that HLA-DRB1 alleles are associated with the susceptibility to sporadic PD in Chinese Han population, among them HLA-DRB1*0301 is a risk allele while the effect of HLA-DRB1*0406 deserves debate.
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影响因子：
3.7
作者：
de la Concha EG;Cavanillas ML;Cénit MC;Urcelay E;Arroyo R;Fernández Ó;Álvarez-Cermeño JC;Leyva L;Villar LM;Núñez C
通讯作者：
Núñez C
影响因子：
5
作者：
Handunnetthi, L.;Ramagopalan, S. V.;Ebers, G. C.;Knight, J. C.
通讯作者：
Knight, J. C.
影响因子：
--
作者：
HASHIMOTO, M;KINOSHITA, T;FUKUNISHI, T
通讯作者：
FUKUNISHI, T
影响因子：
11
作者：
HUGHES, AJ;DANIEL, SE;LEES, AJ
通讯作者：
LEES, AJ
影响因子：
15.9
作者：
Brochard, Vanessa;Combadiere, Behazine;Hunot, Stephane
通讯作者：
Hunot, Stephane