Oocyte differentiation is genetically dissociable from meiosis in mice.
Oocyte differentiation is genetically dissociable from meiosis in mice.
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DOI：
10.1038/ng.2672
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发表时间：
2013-08
期刊：
影响因子：
30.8
通讯作者：
Page, David C.
中科院分区：
文献类型：
--
作者：
Dokshin, Gregoriy A.;Baltus, Andrew E.;Eppig, John J.;Page, David C.
卵子发生是卵巢生殖细胞进行减数分裂并分化为卵子的过程。在小鼠中，Stra8是发生减数分裂的染色体事件所必需的，但它在分化中的作用尚不清楚。在这里，我们报道了Stra8缺陷的卵巢生殖细胞，它们生长并分化成类卵母细胞，合成透明带，将周围的体细胞组织成卵泡，对激素刺激进行排卵，经历不对称的细胞分裂产生极体，并在受精时分裂形成两细胞胚胎。这些事件发生时没有减数分裂前的染色体复制、姐妹染色单体凝聚、突触或重组。因此，卵母细胞的生长和分化在基因上是与减数分裂的染色体事件无关的。这些发现为研究减数分裂和卵母细胞分化对形成功能卵子的独立贡献打开了大门。
Oogenesis is the process by which ovarian germ cells undertake meiosis and differentiate to become eggs. In mice, Stra8 is required for the chromosomal events of meiosis to occur, but its role in differentiation remains unknown. Here we report Stra8-deficient ovarian germ cells that grow and differentiate into oocyte-like cells that synthesize zonae pellucidae, organize surrounding somatic cells into follicles, are ovulated in response to hormonal stimulation, undergo asymmetric cell division to produce a polar body, and cleave to form two-cell embryos upon fertilization. These events occur without premeiotic chromosomal replication, sister chromatid cohesion, synapsis, or recombination. Thus, oocyte growth and differentiation are genetically dissociable from the chromosomal events of meiosis. These findings open to study the independent contributions of meiosis and oocyte differentiation to the making of a functional egg.
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影响因子：
3.5
作者：
Nicholas CR;Haston KM;Grewall AK;Longacre TA;Reijo Pera RA
通讯作者：
Reijo Pera RA
影响因子：
56.9
作者：
Bowles, J;Knight, D;Koopman, P
通讯作者：
Koopman, P
DOI：
10.1089/clo.2007.0031
发表时间：
2007-12-01
期刊：
CLONING AND STEM CELLS
影响因子：
--
作者：
Kerkis, Alexandre;Fonseca, Simone A. S.;Kerkis, Irina
通讯作者：
Kerkis, Irina
影响因子：
56.9
作者：
Lin, Yanfeng;Gill, Mark E.;Page, David C.
通讯作者：
Page, David C.
影响因子：
--
作者：
DONAHUE, RP
通讯作者：
DONAHUE, RP