Driving Ability in Alzheimer Disease Spectrum: Neural Basis, Assessment, and Potential Use of Optic Flow Event-Related Potentials.
Driving Ability in Alzheimer Disease Spectrum: Neural Basis, Assessment, and Potential Use of Optic Flow Event-Related Potentials.
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DOI：
10.3389/fneur.2018.00750
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发表时间：
2018
影响因子：
3.4
通讯作者：
Tobimatsu S
中科院分区：
文献类型：
--
作者：
Yamasaki T;Tobimatsu S
驾驶需要多种认知功能，包括视觉空间感知，并招募广泛的大脑网络。近年来，交通事故中的痴呆，特别是阿尔茨海默病谱（ADS），已成为一个紧迫的社会问题。因此，有必要开发客观、可靠的生物标志物来评价ADS患者的驾驶能力。有趣的是，即使在疾病的早期阶段，ADS患者的特征在于视觉空间功能的损害，例如与自我运动感知相关的径向光流（OF）感知。在过去的十年中，我们已经研究了事件相关电位（ERPs）在ADS中的径向OF反应的可行性，并提出OF-ERPs提供了一个额外的信息，在ADS中的视觉空间知觉的改变。因此，我们假设OF-ERPs可能是ADS驾驶能力的预测生物标志物。在这篇综述中，最近的概念，驾驶在健康人的神经基板首先概述。其次，我们提到了驾驶行为及其脑网络在ADS中的变化。第三，阐述了驾驶能力评价工具的现状。第四，我们描述了与驾驶能力相关的ERP研究。此外，在健康人的OF处理和OF-ERPs的神经基础被提及。最后，描述了OF-ERP在ADS中的应用。本综述的目的是介绍OF-ERPs在ADS驾驶能力评估中的潜在应用。
Driving requires multiple cognitive functions including visuospatial perception and recruits widespread brain networks. Recently, traffic accidents in dementia, particularly in Alzheimer disease spectrum (ADS), have increased and become an urgent social problem. Therefore, it is necessary to develop the objective and reliable biomarkers for driving ability in patients with ADS. Interestingly, even in the early stage of the disease, patients with ADS are characterized by the impairment of visuospatial function such as radial optic flow (OF) perception related to self-motion perception. For the last decade, we have studied the feasibility of event-related potentials (ERPs) in response to radial OF in ADS and proposed that OF-ERPs provided an additional information on the alteration of visuospatial perception in ADS. Hence, we hypothesized that OF-ERPs can be a possible predictive biomarker of driving ability in ADS. In this review, the recent concept of neural substrates of driving in healthy humans are firstly outlined. Second, we mention the alterations of driving performance and its brain network in ADS. Third, the current status of assessment tools for driving ability is stated. Fourth, we describe ERP studies related to driving ability in ADS. Further, the neural basis of OF processing and OF-ERPs in healthy humans are mentioned. Finally, the application of OF-ERPs to ADS is described. The aim of this review was to introduce the potential use of OF-ERPs for assessment of driving ability in ADS.
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DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
影响因子：
9.8
作者：
Biagi L;Crespi SA;Tosetti M;Morrone MC
通讯作者：
Morrone MC
影响因子：
25
作者：
Morrone, MC;Tosetti, M;Burr, DC
通讯作者：
Burr, DC
影响因子：
14
作者：
通讯作者：
--
影响因子：
4
作者：
Hird, Megan A.;Vesely, Kristin A.;Schweizer, Tom A.
通讯作者：
Schweizer, Tom A.