Variability in the rate of 6-mercaptopurine methylation in the erythrocytes, liver and kidney in an Italian population
Variability in the rate of 6-mercaptopurine methylation in the erythrocytes, liver and kidney in an Italian population
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意大利人群红细胞、肝脏和肾脏中 6-巯基嘌呤甲基化率的变异性
DOI：
10.1007/s002280050155
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发表时间：
1996
影响因子：
2.9
通讯作者：
G. Pacifici
中科院分区：
文献类型：
--
作者：
M. Ferroni;G. Marchi;E. Sansone;P. Romeo;P. Giulianotti;A. Pietrabissa;Franco Mosca;G. Pacifici
Objective.红细胞硫嘌呤甲基转移酶（TPMT）的多态性是遗传调节的常染色体共显性性状，所以应该是先天性的。结果。我们测试了这一假设，通过测量TPMT活性在红细胞制剂从成人和新生儿，并观察TPMT活性在成人和新生儿红细胞的多态性分布。新生儿红细胞TPMT活性高于成人红细胞。还研究了肝脏和肾脏中TPMT活性的频率分布。在肾脏中，TPMT活性分为两个亚组，而在肝脏中的分布模式更为复杂。TPMT在红细胞和肝脏从同一主题的活动是相关的，但只有一半的情况下的值落在95%的置信限内，这表明肝脏和/或红细胞TPMT的控制是多因素的。
Objective. The polymorphism of erythrocyte thiopurine methyltransferase (TPMT) is genetically regulated as an autosomal codominant trait, and so should be congenital.Results.We tested this hypothesis by measuring TPMT activity in erythrocyte preparations from adults and newborns and observed polymorphic distribution of TPMT activity in the adult and newborn erythrocytes. The activity of TPMT was higher in red cells from the newborns than adults. The frequency distribution of TPMT activity was also investigated in the liver and kidney. In the kidney, TPMT activity fell into two subgroups, whereas in the liver the distribution pattern was more complex. The activity of TPMT in erythrocytes and liver from the same subject was correlated, but the values of only half the cases fell within the 95% confidence limits, suggesting that the control of hepatic and/or erythrocyte TPMT is multifactorial.
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影响因子：
5.8
作者：
WOODSON, LC;WEINSHILBOUM, RM
通讯作者：
WEINSHILBOUM, RM
人肾组织中的硫嘌呤甲基转移酶同工酶。
DOI：
--
发表时间：
1990
期刊：
Drug metabolism and disposition: the biological fate of chemicals
影响因子：
--
作者：
VanLoon,JA;Weinshilboum,RM
通讯作者：
Weinshilboum,RM
影响因子：
4.6
作者：
Hill, Mark J.;Hughes, Michael;Humar, Abhinav
通讯作者：
Humar, Abhinav
影响因子：
5.8
作者：
J. van Loon;C. Szumlanski;R. Weinshilboum
通讯作者：
J. van Loon;C. Szumlanski;R. Weinshilboum
人硫嘌呤甲基转移酶的药物遗传学：肾-红细胞相关性和免疫滴定研究。
DOI：
--
发表时间：
1982
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Woodson,LC;Dunnette,JH;Weinshilboum,RM
通讯作者：
Weinshilboum,RM