Urine Metabolites Associated with the Dietary Approaches to Stop Hypertension (DASH) Diet: Results from the DASH-Sodium Trial.
Urine Metabolites Associated with the Dietary Approaches to Stop Hypertension (DASH) Diet: Results from the DASH-Sodium Trial.
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DOI：
10.1002/mnfr.202000695
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发表时间：
2021-03
影响因子：
5.2
通讯作者：
Rebholz CM
中科院分区：
文献类型：
--
作者：
Kim H;Lichtenstein AH;Wong KE;Appel LJ;Coresh J;Rebholz CM
以前曾报道过饮食方法停止高血压（DASH）饮食的血清代谢组学标志物。我们在一项独立的临床试验中调查了尿液代谢组学标志物是否相似。在DASH-Sodium试验中，参与者被随机分配到DASH饮食或对照饮食组，并在每个随机饮食组中以随机顺序接受三种钠干预（高、中、低），每次30天。在干预期结束时收集尿样，并分析938种代谢物。我们对代谢组学特征进行了两项比较：1）DASH-高钠（n=199）与对照-高钠（n=193），以及2）DASH-低钠（n=196）与对照-高钠。我们比较了使用多变量线性回归确定的重要代谢物和使用偏最小二乘判别分析确定的前10种有影响的代谢物与DASH试验先前分析的结果。DASH-高钠和DASH-低钠饮食的10种预测代谢物中有9种是相同的。来自DASH试验的大多数候选生物标志物重复。N-甲基脯氨酸，手性肌醇，水苏碱，可可碱复制DASH饮食的有影响力的代谢产物。在血清中鉴定的DASH饮食的候选生物标志物在尿液中复制。复制的有影响的代谢物可能是DASH饮食的客观生物标志物。饮食方法停止高血压（DASH）饮食被推荐为健康饮食。最近的一项研究确定了血清中DASH饮食的候选生物标志物。本研究显示，被鉴定为DASH饮食的前10种预测代谢物的几种血清代谢物在独立人群中复制为DASH饮食的预测尿液代谢物。
Serum metabolomic markers of the Dietary Approaches to Stop Hypertension (DASH) diet were previously reported. We investigated if urine metabolomic markers were similar in an independent clinical trial. In the DASH-Sodium trial, participants were randomly assigned to the DASH diet or control diet, and received three sodium interventions (high, intermediate, low) within each randomized diet group in random order for 30 days each. Urine samples were collected at the end of the intervention period and analyzed for 938 metabolites. We conducted two comparisons of metabolomic profiles: 1) DASH-high sodium (n=199) vs. control-high sodium (n=193), and 2) DASH-low sodium (n=196) vs. control-high sodium. We compared significant metabolites identified using multivariable linear regression and the top 10 influential metabolites identified using partial least-squares discriminant analysis to the results from a previous analysis of the DASH trial. Nine out of 10 predictive metabolites of the DASH-high sodium and DASH-low sodium diets were identical. Most candidate biomarkers from the DASH trial replicated. N-methylproline, chiro-inositol, stachydrine, and theobromine replicated as influential metabolites of DASH diets. Candidate biomarkers of the DASH diet identified in serum replicated in urine. Replicated influential metabolites are likely to be objective biomarkers of the DASH diet. The Dietary Approaches to Stop Hypertension (DASH) diet is recommended as a healthy diet. A recent study identified candidate biomarkers of the DASH diet in serum. The present study revealed that several serum metabolites identified as the top 10 predictive metabolites of the DASH diet replicated as predictive urine metabolites of the DASH diet in an independent population.
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影响因子：
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