Hydroxybenzoic acid isomers and the cardiovascular system.
Hydroxybenzoic acid isomers and the cardiovascular system.
复制标题
羟基苯甲酸异构体和心血管系统。
DOI：
10.1186/1475-2891-13-63
复制
发表时间：
2014-06-19
影响因子：
5.4
通讯作者：
Ganguly P
中科院分区：
文献类型：
--
作者：
Juurlink BH;Azouz HJ;Aldalati AM;AlTinawi BM;Ganguly P
今天，我们开始了解植物化学物质如何影响新陈代谢，细胞信号和基因表达。羟基苯甲酸与水杨酸和水杨苷有关，水杨酸和水杨苷是第一批分离出的具有药理活性的化合物。在这篇综述中，我们研究了一些羟基酚类物质如何有潜力改善与衰老有关的心血管问题，如高血压，动脉粥样硬化和血脂异常。重点研究的化合物包括2，3-二羟基苯甲酸（焦儿茶酸）、2，5-二羟基苯甲酸（龙胆酸）、3，4-二羟基苯甲酸（原儿茶酸）、3，5-二羟基苯甲酸（α-间苯二酚）和3-单羟基苯甲酸。后两种化合物激活羟基羧酸受体，结果是脂肪细胞脂解减少，血脂谱可能改善。其他几种化合物可以激活Nrf 2信号通路，增加抗氧化酶的表达，从而减少氧化应激和相关问题，如导致高血压的内皮功能障碍，以及减少可能导致动脉粥样硬化等问题的全身性炎症。多年来，人们都知道增加水果和蔬菜的消费可以促进健康。我们开始了解特定的植物化学物质是如何产生这种治疗效果的。希波克拉底的格言“让食物成为你的药物，让药物成为你的食物”现在可以通过实验进行测试，这些实验的结果将提高营养学家设计特定健康促进饮食的能力。
Today we are beginning to understand how phytochemicals can influence metabolism, cellular signaling and gene expression. The hydroxybenzoic acids are related to salicylic acid and salicin, the first compounds isolated that have a pharmacological activity. In this review we examine how a number of hydroxyphenolics have the potential to ameliorate cardiovascular problems related to aging such as hypertension, atherosclerosis and dyslipidemia. The compounds focused upon include 2,3-dihydroxybenzoic acid (Pyrocatechuic acid), 2,5-dihydroxybenzoic acid (Gentisic acid), 3,4-dihydroxybenzoic acid (Protocatechuic acid), 3,5-dihydroxybenzoic acid (α-Resorcylic acid) and 3-monohydroxybenzoic acid. The latter two compounds activate the hydroxycarboxylic acid receptors with a consequence there is a reduction in adipocyte lipolysis with potential improvements of blood lipid profiles. Several of the other compounds can activate the Nrf2 signaling pathway that increases the expression of antioxidant enzymes, thereby decreasing oxidative stress and associated problems such as endothelial dysfunction that leads to hypertension as well as decreasing generalized inflammation that can lead to problems such as atherosclerosis. It has been known for many years that increased consumption of fruits and vegetables promotes health. We are beginning to understand how specific phytochemicals are responsible for such therapeutic effects. Hippocrates’ dictum of ‘Let food be your medicine and medicine your food’ can now be experimentally tested and the results of such experiments will enhance the ability of nutritionists to devise specific health-promoting diets.
登录
查看更多内容
影响因子：
5.2
作者：
de Ferrars, Rachel M.;Cassidy, Aedin;Kay, Colin D.
通讯作者：
Kay, Colin D.
DOI：
10.1073/pnas.172398899
发表时间：
2002-09-03
影响因子：
11.1
作者：
Dinkova-Kostova, AT;Holtzclaw, WD;Talalay, P
通讯作者：
Talalay, P
影响因子：
3.9
作者：
Godevac, Dejan;Tesevic, Vele;Stankovic, Miroslava
通讯作者：
Stankovic, Miroslava
影响因子：
1.8
作者：
Gross-Steinmeyer, K;Stapleton, PL;Eaton, DL
通讯作者：
Eaton, DL
影响因子：
3.5
作者：
Exner, M;Hermann, M;Gmeiner, BMK
通讯作者：
Gmeiner, BMK