B cells going viral in the CNS: Dynamics, complexities, and functions of B cells responding to viral encephalitis.
B cells going viral in the CNS: Dynamics, complexities, and functions of B cells responding to viral encephalitis.
复制标题
B细胞在中枢神经系统中的病毒化：B细胞对病毒性脑炎反应的动力学、复杂性和功能。
DOI：
10.1111/imr.13124
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发表时间：
2022-10
影响因子：
8.7
通讯作者：
中科院分区：
文献类型：
--
作者：
多种 DNA 和 RNA 病毒有可能侵入中枢神经系统 (CNS)，对修复和再生能力有限的细胞造成炎症和损伤。虽然罕见，但人类病毒性脑炎通常是致命的，幸存者通常会遭受包括癫痫发作在内的永久性神经系统后遗症。现有的治疗选择极其有限，主要依靠疫苗、抗病毒药物或支持性护理。许多病毒性中枢神经系统感染的特征是脑脊液 (CSF) 中存在抗病毒抗体，这表明保护性抗体分泌细胞的局部维持。然而，维持这些体液反应的机制尚不清楚。此外，虽然病毒性脑炎和自身免疫性脑炎都与中枢神经系统招募不同的 B 细胞亚群有关，但它们除了产生抗体之外的保护性和致病性作用才刚刚开始被了解。本综述将重点关注 B 细胞反应与病毒性中枢神经系统感染的相关性，重点关注鞘内免疫的重要性以及对自身免疫的潜在贡献。具体来说，它将总结临床样本中B细胞激活、分化、迁移和定位的最新数据以及急性和持续性病毒性脑炎的实验模型。
A diverse number of DNA and RNA viruses have the potential to invade the central nervous system (CNS), causing inflammation and injury to cells that have a limited capacity for repair and regeneration. While rare, viral encephalitis in humans is often fatal and survivors commonly suffer from permanent neurological sequelae including seizures. Established treatment options are extremely limited, predominantly relying on vaccines, antivirals, or supportive care. Many viral CNS infections are characterized by the presence of antiviral antibodies in the cerebral spinal fluid (CSF), indicating local maintenance of protective antibody secreting cells. However, the mechanisms maintaining these humoral responses are poorly characterized. Furthermore, while both viral and autoimmune encephalitis are associated with the recruitment of diverse B cell subsets to the CNS, their protective and pathogenic roles aside from antibody production are just beginning to be understood. This review will focus on the relevance of B cell responses to viral CNS infections, with an emphasis on the importance of intrathecal immunity and the potential contribution to autoimmunity. Specifically, it will summarize the newest data characterizing B cell activation, differentiation, migration, and localization in clinical samples as well as experimental models of acute and persistent viral encephalitis.
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影响因子：
3
作者：
DiSano KD;Stohlman SA;Bergmann CC
通讯作者：
Bergmann CC
DOI：
10.3390/v12090988
发表时间：
2020-09-05
期刊：
Viruses
影响因子：
--
作者：
Bartlett ML;Griffin DE
通讯作者：
Griffin DE
DOI：
10.1590/1980-57642021dn15-020002
发表时间：
2021-04
期刊：
Dementia & neuropsychologia
影响因子：
--
作者：
Campos EMN;Rodrigues LD;Oliveira LF;Dos Santos JCC
通讯作者：
Dos Santos JCC
DOI：
10.1126/science.abf9277
发表时间：
2021-07-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Brioschi S;Wang WL;Peng V;Wang M;Shchukina I;Greenberg ZJ;Bando JK;Jaeger N;Czepielewski RS;Swain A;Mogilenko DA;Beatty WL;Bayguinov P;Fitzpatrick JAJ;Schuettpelz LG;Fronick CC;Smirnov I;Kipnis J;Shapiro VS;Wu GF;Gilfillan S;Cella M;Artyomov MN;Kleinstein SH;Colonna M
通讯作者：
Colonna M
影响因子：
5.4
作者：
Chen, Shih-Heng;Yao, Hui-Wen;Chen, Shun-Hua
通讯作者：
Chen, Shun-Hua