VEGF inhibition, hypertension, and renal toxicity.
VEGF inhibition, hypertension, and renal toxicity.
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DOI：
10.1007/s11912-012-0242-z
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发表时间：
2012-08
影响因子：
4.7
通讯作者：
Garovic, Vesna D.
中科院分区：
文献类型：
--
作者：
Hayman, Suzanne R.;Leung, Nelson;Grande, Joseph P.;Garovic, Vesna D.
关键词：
抗血管生成剂作为晚期实体瘤治疗手段的一部分，在一些情况下已成为标准治疗，特别是对于肾细胞癌、非小细胞肺癌、结直肠癌和胃肠道间质瘤。这些药物主要靶向血管内皮生长因子（VEGF）和/或其受体，包括贝伐单抗（一种针对VEGF的人源化单克隆抗体），以及靶向几种受体酪氨酸激酶（RTK）（包括VEGF受体）的酪氨酸激酶抑制剂。这些治疗作为血管生成药物的一般类别，已显示具有直接或间接归因于其抗VEGF作用的常见不良血管作用，包括高血压、肾血管损伤（通常表现为蛋白尿和血栓性微血管病）和充血性心力衰竭。了解这些常见的副作用及其潜在的机制，可以更准确和迅速的诊断，及时的临床干预，以及合理和标准治疗的发展。这些措施可以最大限度地减少患者发病率和死亡率，不仅通过治疗副作用，而且通过最大限度地减少对潜在恶性肿瘤治疗的中断，以及改善患者的生活质量。
The use of anti-angiogenic agents as part of the therapeutic armamentarium for advanced stage solid tumors has become standard of care in several instances, particularly for renal cell carcinoma, non-small cell lung carcinoma, colorectal carcinoma, and gastrointestinal stromal tumors. These agents primarily target vascular endothelial growth factor (VEGF) and/or its receptors, and include bevacizumab, a humanized monoclonal antibody against VEGF, as well as tyrosine kinase inhibitors that target several receptor tyrosine kinases (RTK), including VEGF receptors. These therapies, as a general class of angiogenic medications, have been shown to have common adverse vascular effects attributable directly or indirectly to their anti-VEGF effects, including hypertension, renal vascular injury, often manifested by proteinuria and thrombotic microangiopathy, and congestive heart failure. Knowledge of these common side effects and their underlying mechanisms may allow for more accurate and prompt diagnoses, timely clinical interventions, and the development of rational and standard treatments. These measures may minimize patient morbidity and mortality, not only by the treatment of side effects, but also by minimizing the disruption of treatment of the underlying malignancy, as well as improving patient quality of life.
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影响因子：
11.5
作者：
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通讯作者：
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影响因子：
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DOI：
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