Compartment boundaries

Compartment boundaries
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房室边界

DOI:
10.4161/fly.4.3.12173
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发表时间:
2010
期刊:
Fly
影响因子:
1.2
通讯作者:
Christian Dahmann
Christian Dahmann
中科院分区:
生物学4区
文献类型:
--
作者:
Daiki Umetsu;Christian Dahmann

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将增殖的组织细分为不混合的细胞组,称为隔室,是动物发育的常见过程。相邻隔室之间的信号传导诱导形成周围组织图案的形态发生素的局部表达。在组织生长过程中,区室之间的尖锐和笔直的边界稳定了这种形态发生素的来源,因此,对于图案形成至关重要。维持区室边界所需的信号通路已经确定,但维持区室边界的物理机制仍然难以捉摸。最近的数据表明,在果蝇中,基于肌动球蛋白的机械张力对细胞键的局部增加对于维持区室边界至关重要。
The subdivision of proliferating tissues into groups of non-intermingling sets of cells, termed compartments, is a common process of animal development. Signaling between adjacent compartments induces the local expression of morphogens that pattern the surrounding tissue. Sharp and straight boundaries between compartments stabilize the source of such morphogens during tissue growth and, thus, are of crucial importance for pattern formation. Signaling pathways required to maintain compartment boundaries have been identified, yet the physical mechanisms that maintain compartment boundaries remained elusive. Recent data now show that a local increase in actomyosin-based mechanical tension on cell bonds is vital for maintaining compartment boundaries in Drosophila.
DOI: 10.1242/dev.124.20.4053
发表时间: 1997
期刊: Development (Cambridge, England)
影响因子: --
作者:
Blair,SS;Ralston,A
通讯作者: Ralston,A
DOI: 10.1101/gad.14.11.1377
发表时间: 2000-06
影响因子: 10.5
作者:
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期刊: Developmental cell
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