Structural correlates of semantic and phonemic fluency ability in first and second languages.
Structural correlates of semantic and phonemic fluency ability in first and second languages.
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DOI：
10.1093/cercor/bhp023
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发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Price CJ
中科院分区：
文献类型：
--
作者：
Grogan A;Green DW;Ali N;Crinion JT;Price CJ
类别和字母流畅性任务通常用于临床研究语音产生的语义和语音过程，但由于任务的相对不受约束的性质，这些过程的神经相关性很难用功能性神经成像来建立。本研究探讨是否差异表现在语义（类别）和音位（字母）流畅性在神经正常的参与者反映在区域灰质密度。与会者是59名精通两种语言的发言者。我们的研究结果证实了左下颞叶皮层在语义相对于音素流畅性的重要性，并显示这种效果是相同的第一语言（L1）和第二语言（L2）。此外，我们发现，前补充运动区（前SMA）和头的尾状核双边与音位比语义流畅性，这种效果是更强的L2比L1在尾状核。为了进一步验证这些结构的结果，我们重新分析了以前报道的功能数据，发现前SMA和左尾状核激活是高于语音比语义流畅。根据我们的研究结果，我们还预测，病变的前SMA和尾状核可能有更大的影响语音比语义流畅性，特别是在L2扬声器。
Category and letter fluency tasks are commonly used clinically to investigate the semantic and phonological processes central to speech production, but the neural correlates of these processes are difficult to establish with functional neuroimaging because of the relatively unconstrained nature of the tasks. This study investigated whether differential performance on semantic (category) and phonemic (letter) fluency in neurologically normal participants was reflected in regional gray matter density. The participants were 59 highly proficient speakers of 2 languages. Our findings corroborate the importance of the left inferior temporal cortex in semantic relative to phonemic fluency and show this effect to be the same in a first language (L1) and second language (L2). Additionally, we show that the pre-supplementary motor area (pre-SMA) and head of caudate bilaterally are associated with phonemic more than semantic fluency, and this effect is stronger for L2 than L1 in the caudate nuclei. To further validate these structural results, we reanalyzed previously reported functional data and found that pre-SMA and left caudate activation was higher for phonemic than semantic fluency. On the basis of our findings, we also predict that lesions to the pre-SMA and caudate nuclei may have a greater impact on phonemic than semantic fluency, particularly in L2 speakers.
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