Mind the brain gap: The worldwide distribution of neuroimaging research on adolescent depression.

Mind the brain gap: The worldwide distribution of neuroimaging research on adolescent depression.
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DOI:
10.1016/j.neuroimage.2021.117865
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发表时间:
2021-05-01
期刊:
影响因子:
5.7
通讯作者:
Kieling C
Kieling C
中科院分区:
医学1区
文献类型:
--
作者:
Battel L;Cunegatto F;Viduani A;Fisher HL;Kohrt BA;Mondelli V;Swartz JR;Kieling C

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青少年占世界人口的四分之一,其中约90%生活在低收入和中等收入国家。抑郁症的发病率在青春期显著增加,使该疾病成为该年龄组疾病相关残疾的主要原因。然而,大多数关于青少年抑郁症的研究都是在高收入国家(HIC)进行的。为了确定这种差异在神经影像学研究中的作用程度,我们对文献进行了系统回顾。共确定了148项研究,其中4,729名青少年抑郁症患者的神经影像学数据可用。当按收入组分层时,122项(82%)研究来自高收入国家,26项(18%)研究来自低收入国家,分别涉及3,705名和1,024名青少年抑郁症患者。观察到国家人均收入与样本大小之间存在正的斯皮尔曼等级相关(rs =0.673,p = 0.023)。我们的研究结果支持以前的报告,显示研究数量和世界各地区青少年人口之间存在很大差异。未来的研究比较神经影像学结果在人群中从HIC和LMIC可能提供独特的见解,以提高我们的神经生物学过程的理解抑郁症的发展。
Adolescents comprise one fourth of the world’s population, with about 90% of them living in low- and middle-income countries (LMICs). The incidence of depression markedly increases during adolescence, making the disorder a leading cause of disease-related disability in this age group. However, most research on adolescent depression has been performed in high-income countries (HICs). To ascertain the extent to which this disparity operates in neuroimaging research, a systematic review of the literature was performed. A total of 148 studies were identified, with neuroimaging data available for 4,729 adolescents with depression. When stratified by income group, 122 (82%) studies originated from HICs, while 26 (18%) were conducted in LMICs, for a total of 3,705 and 1,024 adolescents with depression respectively. A positive Spearman rank correlation was observed between country per capita income and sample size (rs =0.673, p = 0.023). Our results support the previous reports showing a large disparity between the number of studies and the adolescent population per world region. Future research comparing neuroimaging findings across populations from HICs and LMICs may provide unique insights to enhance our understanding of the neurobiological processes underlying the development of depression.
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