Functional brain imaging studies of youth depression: a systematic review.
Functional brain imaging studies of youth depression: a systematic review.
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DOI：
10.1016/j.nicl.2013.11.009
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发表时间：
2014
影响因子：
4.2
通讯作者：
Harrison, Ben J.
中科院分区：
文献类型：
--
作者：
Kerestes, Rebecca;Davey, Christopher G.;Stephanou, Katerina;Whittle, Sarah;Harrison, Ben J.
人们越来越有兴趣了解青年重性抑郁症（MDD）的神经生物学，特别是在神经影像学研究的背景下。这篇系统性综述提供了一个及时全面的功能磁共振成像（fMRI）文献在青年MDD。使用PubMED、PsycINFO和Science Direct数据库进行文献检索，以识别年龄分别为13-18岁和19-25岁的年轻和老年MDD患者的fMRI研究。28项研究集中在5个功能成像领域，即情绪加工，认知控制，情感认知，奖励加工和静息态功能连接。在这五个区域中，包括前扣带、腹内侧和眶额皮质以及杏仁核在内的“扩展内侧网络”区域的活动升高最为一致。在大多数情况下，在年轻的青少年的研究结果并没有显着差异，从那些在年长的青年，然而，在这两个群体的研究结果相比，成年人的一般比较表明，在认知控制和情感认知领域的差异。青年抑郁症的特点是异常激活的腹内侧额叶区，前扣带回和杏仁核，这是广泛的内侧网络区域的抑郁症的病理生理学中的牵连作用相一致。未来的纵向研究，探讨神经发育变化和青春期成熟的影响，涉及青年抑郁症的大脑系统将提供一个更全面的青年抑郁症的神经生物学模型。我们提供了一个系统的审查功能磁共振成像研究在青年抑郁症。在扩展的内侧前额叶网络区域发现异常功能。与成人MDD相比，青年MDD的研究结果显示出一些重要的差异。未来的研究需要关注青春期对内侧网络活动的影响。纵向研究将有助于为青年MDD的神经生物学模型提供信息。
There is growing interest in understanding the neurobiology of major depressive disorder (MDD) in youth, particularly in the context of neuroimaging studies. This systematic review provides a timely comprehensive account of the available functional magnetic resonance imaging (fMRI) literature in youth MDD. A literature search was conducted using PubMED, PsycINFO and Science Direct databases, to identify fMRI studies in younger and older youth with MDD, spanning 13–18 and 19–25 years of age, respectively. Twenty-eight studies focusing on 5 functional imaging domains were identified, namely emotion processing, cognitive control, affective cognition, reward processing and resting-state functional connectivity. Elevated activity in “extended medial network” regions including the anterior cingulate, ventromedial and orbitofrontal cortices, as well as the amygdala was most consistently implicated across these five domains. For the most part, findings in younger adolescents did not differ from those in older youth; however a general comparison of findings in both groups compared to adults indicated differences in the domains of cognitive control and affective cognition. Youth MDD is characterized by abnormal activations in ventromedial frontal regions, the anterior cingulate and amygdala, which are broadly consistent with the implicated role of medial network regions in the pathophysiology of depression. Future longitudinal studies examining the effects of neurodevelopmental changes and pubertal maturation on brain systems implicated in youth MDD will provide a more comprehensive neurobiological model of youth depression. We provide a systematic review of fMRI studies in youth MDD. Abnormal function is found in regions of the extended medial prefrontal network. Findings in youth MDD show some important differences compared to adult MDD. Future studies need to focus on the effects of puberty on medial network activity. Longitudinal studies will help inform neurobiological models of youth MDD.
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DOI：
10.1111/j.1532-7795.2010.00712.x
发表时间：
2011-03-01
期刊：
Journal of research on adolescence : the official journal of the Society for Research on Adolescence
影响因子：
--
作者：
Casey B;Jones RM;Somerville LH
通讯作者：
Somerville LH
影响因子：
--
作者：
Beesdo, Katja;Lau, Jennifer Y. F.;Guyer, Amanda E.;McClure-Tone, Erin B.;Monk, Christopher S.;Nelson, Eric E.;Fromm, Stephen J.;Goldwin, Michelle A.;Wittchen, Hans-Ulrich;Leibenluft, Ellen;Erns, Monique;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
DOI：
10.1176/appi.neuropsych.19.3.274
发表时间：
2007-06-01
影响因子：
2.9
作者：
Anand, Amit;Li, Yu;Lowe, Mark J.
通讯作者：
Lowe, Mark J.
影响因子：
1.7
作者：
Beauregard, Mario;Paquette, Vincent;Levesque, Johanne
通讯作者：
Levesque, Johanne
影响因子：
6.6
作者：
Casey, B. J.;Getz, Sarah;Galvan, Adriana
通讯作者：
Galvan, Adriana