Bistability coordinates activation of the EGFR and DPP pathways in Drosophila vein differentiation.
Bistability coordinates activation of the EGFR and DPP pathways in Drosophila vein differentiation.
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DOI：
10.1038/msb.2009.35
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发表时间：
2009
影响因子：
9.9
通讯作者：
Li, Willis X.
中科院分区：
文献类型：
--
作者：
Yan, Shian-Jang;Zartman, Jeremiah J.;Zhang, Minjie;Scott, Anthony;Shvartsman, Stanislav Y.;Li, Willis X.
Cell differentiation in developing tissues is controlled by a small set of signaling pathways, which must coordinate the timing and levels of activation to ensure robust and precise outcomes. Highly coordinated activation of signaling pathways can result from cross-regulatory interactions in multi-pathway networks. Here we explore the dynamics and function of pathway coordination between the EGFR and DPP pathways during Drosophila wing-vein differentiation. We show that simultaneous activation of both the EGFR and DPP pathways must be maintained for vein cell differentiation and that above-threshold ectopic activation of either pathway is sufficient to drive vein cell differentiation outside the proveins. The joint activation of the EGFR and DPP signaling systems is ensured by a positive feedback loop, in which the two pathways stimulate each other at the level of ligand production.
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影响因子：
64.5
作者：
Freeman, M
通讯作者：
Freeman, M
影响因子：
64.5
作者：
Laslo, Peter;Spooner, Chauncey J.;Singh, Harinder
通讯作者：
Singh, Harinder
影响因子：
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作者：
NAMBU, JR;FRANKS, RG;CREWS, ST
通讯作者：
CREWS, ST
影响因子：
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作者：
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通讯作者：
De Celis, JF
DOI：
10.1073/pnas.0308265100
发表时间：
2004-02-17
影响因子：
11.1
作者：
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通讯作者：
Sontag, ED