Biomechanical characterization of aortic valve tissue in humans and common animal models.
Biomechanical characterization of aortic valve tissue in humans and common animal models.
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DOI：
10.1002/jbm.a.34099
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发表时间：
2012-06
影响因子：
4.9
通讯作者：
Sun, Wei
中科院分区：
文献类型：
--
作者：
Martin, Caitlin;Sun, Wei
主动脉瓣疾病在老年患者中以一种不断升级的方式发展。目前的治疗方法，包括全瓣膜置换术和瓣膜修复技术，仍然不是最理想的。深入了解动物和人类瓣膜的组织特性，特别是它们的差异，对于建立临床前动物模型和评估新的瓣膜治疗技术(如经导管瓣膜介入和组织工程瓣膜)至关重要。本研究的目的是描述和比较健康的绵羊、猪和人的主动脉瓣叶的生物力学特性和组织结构。对10只羊(~1岁)、10只猪(6~9月龄)和10只老年人(80.6±8.34)个心脏的主动脉瓣叶的双轴力学性能进行了定量研究。通过组织学技术分析组织微结构。老化的人主动脉瓣叶的顺应性明显低于羊叶和猪叶，其中羊叶的顺应性最强。组织学分析揭示了物种之间的结构差异：人和猪的小叶比绵羊的小叶含有更多的胶原和弹性蛋白。6-9个月龄猪模型和1岁羊模型的主动脉瓣组织与老年人相比，在力学和结构上存在显著差异，这表明这些动物模型可能不能代表典型的主动脉瓣置换患者。
Aortic valve disease develops in an escalating fashion in elderly patients. Current treatments including total valve replacement and valve repair techniques are still suboptimal. A thorough understanding of the animal and human valve tissue properties, particularly their differences, is crucial for the establishment of preclinical animal models and strategies for evaluating new valve treatment techniques, such as transcatheter valve intervention and tissue engineered valves. The goal of this study was to characterize and compare the biomechanical properties and histological structure of healthy ovine, porcine, and human aortic valve leaflets. The biaxial mechanical properties of the aortic valve leaflets of 10 ovine (~1 year), 10 porcine (6–9 months), and 10 aged human (80.6 ± 8.34) hearts were quantified. Tissue microstructure was analyzed via histological techniques. Aged human aortic valve leaflets were significantly less compliant than both ovine and porcine leaflets, with the ovine leaflets being the most compliant. Histological analysis revealed structural differences between the species: the human and porcine leaflets contained more collagen and elastin than the ovine leaflets. Significant mechanical and structural differences in the aortic valve tissues of 6- to 9-month-old porcine models and 1-year-old ovine models with respect to those of aged humans, suggest that these animal models may not be representative of the typical patient undergoing aortic valve replacement.
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DOI：
10.1016/s0735-1097(96)00563-3
发表时间：
1997-03-01
影响因子：
24
作者：
Stewart, BF;Siscovick, D;Otto, CM
通讯作者：
Otto, CM
影响因子：
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作者：
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影响因子：
37.8
作者：
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通讯作者：
Haverich, Axel
DOI：
10.1115/1.2768111
发表时间：
2007-10-01
影响因子：
1.7
作者：
Stella, John A.;Sacks, Michael S.
通讯作者：
Sacks, Michael S.