AXL Receptor in Breast Cancer: Molecular Involvement and Therapeutic Limitations.
AXL Receptor in Breast Cancer: Molecular Involvement and Therapeutic Limitations.
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DOI：
10.3390/ijms21228419
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发表时间：
2020-11-10
影响因子：
5.6
通讯作者：
Ciuffreda L
中科院分区：
文献类型：
--
作者：
Falcone I;Conciatori F;Bazzichetto C;Bria E;Carbognin L;Malaguti P;Ferretti G;Cognetti F;Milella M;Ciuffreda L
乳腺癌是首批受益于靶向治疗的恶性肿瘤之一，即针对特定标记物的治疗。针对HER2的抑制剂就是一个重要的例子，它们提高了大量患者的预期寿命。因此，研究新的生物标志物始终是当前和重要的。AXL是Tyro-3、AXL和Mer()亚家族的成员，目前在许多肿瘤中被认为是一个预测和预后的生物标志物，主要是乳腺癌。它的致癌作用使其成为开发新的药理药物的理想靶点；此外，它最近作为免疫调节剂的作用使Axl对参与研究癌症与肿瘤微环境(TME)之间相互作用的研究人员特别有吸引力。与家族的其他成员相比，所有这些特点都是AXL的特征。在这篇综述中，我们将阐述Axl在乳腺肿瘤细胞中的生物学作用，重点介绍它的分子和生物学特性，它参与肿瘤进展的过程，以及它作为正在进行的临床试验的靶点的意义。
Breast cancer was one of the first malignancies to benefit from targeted therapy, i.e., treatments directed against specific markers. Inhibitors against HER2 are a significant example and they improved the life expectancy of a large cohort of patients. Research on new biomarkers, therefore, is always current and important. AXL, a member of the TYRO-3, AXL and MER (TAM) subfamily, is, today, considered a predictive and prognostic biomarker in many tumor contexts, primarily breast cancer. Its oncogenic implications make it an ideal target for the development of new pharmacological agents; moreover, its recent role as immune-modulator makes AXL particularly attractive to researchers involved in the study of interactions between cancer and the tumor microenvironment (TME). All these peculiarities characterize AXL as compared to other members of the TAM family. In this review, we will illustrate the biological role played by AXL in breast tumor cells, highlighting its molecular and biological features, its involvement in tumor progression and its implication as a target in ongoing clinical trials.
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通过辐射和靶向AXL重新编程免疫学微环境。
影响因子：
16.6
作者：
通讯作者：
--
影响因子：
37.3
作者：
Du Z;Lovly CM
通讯作者：
Lovly CM
影响因子：
8
作者：
通讯作者：
--
DOI：
10.1073/pnas.0909333107
发表时间：
2010-01-19
影响因子：
11.1
作者：
Gjerdrum, Christine;Tiron, Crina;Lorens, James B.
通讯作者：
Lorens, James B.
影响因子：
11.2
作者：
Abba, Martin C.;Fabris, Victoria T.;Aldaz, C. Marcelo
通讯作者：
Aldaz, C. Marcelo