Internal State: Dynamic, Interconnected Communication Loops Distributed Across Body, Brain, and Time.
Internal State: Dynamic, Interconnected Communication Loops Distributed Across Body, Brain, and Time.
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DOI：
10.1093/icb/icab101
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发表时间：
2021-10-04
影响因子：
2.6
通讯作者：
Wasserman S
中科院分区：
文献类型：
--
作者：
Kanwal JK;Coddington E;Frazer R;Limbania D;Turner G;Davila KJ;Givens MA;Williams V;Datta SR;Wasserman S
内部状态深刻地改变了感知和行为。例如，一只饥饿的苍蝇可能会接近并吃掉它不喜欢的食物。群居型蝾螈可能会在捕食者面前保持活跃，而独居型蝾螈则会试图逃跑。然而，内部状态的定义是流动的和不明确的。作为一个跨越五个职业阶段（从本科生到正教授）和六个学术机构的跨学科学者小组，我们聚集在一起，试图提供一个内部状态的操作定义，这可能有助于理解神经系统的行为和功能，在与个体相关的时间尺度上。从这个角度来看，我们建议通过一个以身体和大脑内部和之间的动态和相互关联的通信循环为中心的综合框架来定义内部状态。这个框架是由神经生物学家、行为学家、生理学家和内分泌学家使用的历史和当代范式的综合而成的。我们认为内部状态是由空间分布的网络（身体-大脑通信回路）和时间分布的机制组成的，这些机制将神经回路、生理和行为编织在一起。考虑到内部状态运作的广泛的空间和时间尺度——因此它可以被广泛地定义——我们选择将我们的定义锚定在身体上。在这里，我们专注于强调身体到大脑信号的研究；身体代表内分泌信号，大脑代表感觉信号。这种内部状态的综合框架有可能将科学家研究身体-大脑相互作用时经常使用的不同范式联合起来。我们邀请其他人加入我们，因为我们检查方法和质疑假设，以研究内部状态的潜在机制和时间动态。
Internal state profoundly alters perception and behavior. For example, a starved fly may approach and consume foods that it would otherwise find undesirable. A socially engaged newt may remain engaged in the presence of a predator, whereas a solitary newt would otherwise attempt to escape. Yet, the definition of internal state is fluid and ill-defined. As an interdisciplinary group of scholars spanning five career stages (from undergraduate to full professor) and six academic institutions, we came together in an attempt to provide an operational definition of internal state that could be useful in understanding the behavior and the function of nervous systems, at timescales relevant to the individual. In this perspective, we propose to define internal state through an integrative framework centered on dynamic and interconnected communication loops within and between the body and the brain. This framework is informed by a synthesis of historical and contemporary paradigms used by neurobiologists, ethologists, physiologists, and endocrinologists. We view internal state as composed of both spatially distributed networks (body–brain communication loops), and temporally distributed mechanisms that weave together neural circuits, physiology, and behavior. Given the wide spatial and temporal scales at which internal state operates—and therefore the broad range of scales at which it could be defined—we choose to anchor our definition in the body. Here we focus on studies that highlight body-to-brain signaling; body represented in endocrine signaling, and brain represented in sensory signaling. This integrative framework of internal state potentially unites the disparate paradigms often used by scientists grappling with body–brain interactions. We invite others to join us as we examine approaches and question assumptions to study the underlying mechanisms and temporal dynamics of internal state.
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DOI：
10.1126/science.1202839
发表时间：
2011-06-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bushey D;Tononi G;Cirelli C
通讯作者：
Cirelli C
影响因子：
29.3
作者：
Brette, Romain
通讯作者：
Brette, Romain
影响因子：
1.7
作者：
Cisek, Paul
通讯作者：
Cisek, Paul
影响因子：
19.6
作者：
Ahamed, Tosif;Costa, Antonio C.;Stephens, Greg J.
通讯作者：
Stephens, Greg J.
影响因子：
4.8
作者：
Coddington, Emma;Lewis, Christine;Moore, Frank L.
通讯作者：
Moore, Frank L.