To Which Lineage Do Tumor Necrosis Factor Receptor Type I−Positive Proinflammatory Cells Belong? Comment on the Article by Schmidt et al
To Which Lineage Do Tumor Necrosis Factor Receptor Type I−Positive Proinflammatory Cells Belong? Comment on the Article by Schmidt et al
复制标题
肿瘤坏死因子受体 Iâ 型阳性促炎细胞属于哪个谱系？
DOI：
10.1002/art.38655
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发表时间：
1962
影响因子：
13.3
通讯作者：
Wagner U.
中科院分区：
文献类型：
--
作者：
Schubert K;Meusch U;Scholz R;Rossol M;Wagner U.
我们怀着极大的兴趣阅读了施密特等人最近的报告，其中他们描述了肿瘤坏死因子受体I型（TNFRI）在类风湿性关节炎（RA）发病机制中的促炎作用（1）。这项研究强调，TNFRI信号转导是导致体外培养的滑膜单核细胞（MNCs）中促炎细胞因子和趋化因子产生的主要途径。TNFRI的选择性阻断被认为是RA的潜在治疗方法，其可能上级于TNF配体阻断，因为其保留了有益的TNFRII信号传导。
We read with great interest the recent report by Schmidt et al, in which they described the proinflammatory role of tumor necrosis factor receptor type I (TNFRI) in the pathogenesis of rheumatoid arthritis (RA)(1). This study highlights that TNFRI signaling is the dominant pathway leading to proinflammatory cytokine and chemokine production in ex vivocultured synovial membrane mononuclear cells (MNCs). Selective blockade of TNFRI is suggested as a potentially therapeutic approach in RA that might be superior to TNF ligand blockade, because it preserves beneficial TNFRII signaling.
影响因子：
--
作者：
Rossol, Manuela;Schubert, Kristin;Wagner, Ulf
通讯作者：
Wagner, Ulf
影响因子：
5
作者：
van Blokland, SCA;Wierenga-Wolf, AF;Versnel, MA
通讯作者：
Versnel, MA