Ideomotor apraxia in agrammatic and logopenic variants of primary progressive aphasia.
Ideomotor apraxia in agrammatic and logopenic variants of primary progressive aphasia.
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DOI：
10.1007/s00415-013-6839-9
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发表时间：
2013-06
影响因子：
6
通讯作者：
Josephs KA
中科院分区：
文献类型：
--
作者：
Adeli A;Whitwell JL;Duffy JR;Strand EA;Josephs KA
很少有研究检查原发性进行性失语症患者的实践。本研究的目的是检查原发性进行性失语症的逻辑缺失和语法缺失变体患者的思维失用症的模式和严重程度，并确定是否存在与特定神经解剖结构异常相关的思维失用症。根据已发表的标准，前瞻性招募原发性进行性失语患者并进行分类。使用西方失语症成套测验的失用症分测验，对所有诊断为原发性进行性失语症的语法缺失和逻辑缺失变体的受试者进行了识别性失用症的模式和严重程度检查。研究包括47名受试者，21名被诊断为原发性进行性失语症的无语法变体，26名被诊断为原发性进行性失语症的无逻辑变体。失语症患者的发病年龄大于逻辑缺失型失语症患者（67.2岁vs 61.7岁，p = 0.02），但评估前病程无差异。逻辑缺失型失语症患者在简易精神状态检查中表现出更多的认知障碍（语法缺失= 26.7/30，逻辑缺失= 22/30，p = 0.002），并且根据西方失语症组合失语商（语法缺失= 82.3，逻辑缺失= 75.2，p = 0.11）测量，语言障碍有更严重的趋势。西方失语症电池失语商数与完全性失用症、工具性失用症和复杂性失用症之间存在较强的相关性，而与上肢失用症之间存在平均相关性，与面部失用症之间存在中度相关性。在调整了年龄、精神状态表现和西方失语症电池失语商评分后，语法性失语症患者的总失用症（p = 0.004）、面部失用症（p = 0.03）、工具性失用症（p = 0.0006）和复杂性失用症（p = 0.0006）的程度高于逻辑缺乏性失语症患者。原发性进行性失语症的语法缺失型与更大的实践缺陷相关，但认知障碍比逻辑缺失型更少。意识运用失用症的出现与左侧运动前区皮质的灰质损失相关，并延伸到运动皮质。这些研究结果表明，虽然一些受影响的地区在语法和logopenic变量的原发性进行性失语症重叠，有一个地区，是更受影响的语法变量比logopenic变量，占更大的关联语法性失语症与失用症。
There are few studies examining praxis in subjects with primary progressive aphasia. The aim of this study was to examine the pattern and severity of ideomotor apraxia in subjects with logopenic and agrammatic variants of primary progressive aphasia and to determine if the presence of ideomotor apraxia correlated with specific neuroanatomical structural abnormalities. Subjects with primary progressive aphasia were prospectively recruited and classified according to published criteria. Using the apraxia subtest of the Western Aphasia Battery, pattern and severity of ideomotor apraxia was examined in all subjects diagnosed with agrammatic and logopenic variants of primary progressive aphasia. The study included 47 subjects, 21 diagnosed with agrammatic variant of primary progressive aphasia and 26 with logopenic variant primary progressive aphasia. Subjects with agrammatic aphasia were older at onset than the logopenic variant (67.2 versus 61.7 years, p=0.02), but there was no difference in illness duration prior to evaluation. Those with logopenic aphasia showed more cognitive impairment on the Mini-Mental Status Examination (agrammatic=26.7/30, logopenic=22/30, p=0.002), and a trend for more severe language impairment as measured by Western Aphasia Battery-Aphasia Quotient (agrammatic=82.3, logopenic=75.2, p=0.11). Strong correlations were found between Western Aphasia Battery-Aphasia Quotient and total apraxia, instrumental apraxia, and complex apraxia, while average correlation were seen with upper limb apraxia and modest correlation with facial apraxia. After adjusting for age, mental status performance, and Western Aphasia Battery-Aphasia Quotient score, those with agrammatic aphasia had a higher degree of total apraxia (p=0.004), facial apraxia (p=0.03), instrumental apraxia (p=0.0006), and complex apraxia (p=0.0006) than those with logopenic aphasia. The agrammatic variant of primary progressive aphasia was associated with greater praxis deficits but less cognitive impairment than the logopenic variant. The presence of ideomotor apraxia was associated with grey matter loss in the left lateral premotor cortex with extension into the motor cortex. These findings suggest that although some affected areas in the agrammatic and logopenic variants of primary progressive aphasia overlap, there exists an area that is more affected in the agrammatic variant than the logopenic variant that accounts for the greater association of agrammatic aphasia with apraxia.
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影响因子：
2.5
作者：
Baba, Yasuhiko;Putzke, John D.;Dickson, Dennis W.
通讯作者：
Dickson, Dennis W.
DOI：
10.1007/s12031-011-9589-0
发表时间：
2011-11
期刊：
Journal of molecular neuroscience : MN
影响因子：
--
作者：
Dickson DW;Kouri N;Murray ME;Josephs KA
通讯作者：
Josephs KA
影响因子：
6
作者：
DELLASALA, S;LUCCHELLI, F;SPINNLER, H
通讯作者：
SPINNLER, H
影响因子：
--
作者：
Huey, Edward D.;Pardini, Matteo;Grafman, Jordan
通讯作者：
Grafman, Jordan
影响因子：
14.5
作者：
GESCHWIN.N
通讯作者：
GESCHWIN.N