Aliphatic hyperbranched polyester: a new building block in the construction of multifunctional nanoparticles and nanocomposites.
Aliphatic hyperbranched polyester: a new building block in the construction of multifunctional nanoparticles and nanocomposites.
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DOI：
10.1021/la9037843
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发表时间：
2010-04-20
期刊：
影响因子：
--
通讯作者：
Perez JM
中科院分区：
文献类型：
--
作者：
Santra S;Kaittanis C;Perez JM
在此，我们报告的多功能超支化聚酯基纳米粒子和纳米复合材料的设计和合成的性能范围从磁性，荧光，抗氧化剂和X射线对比度。这些纳米结构的制造，实现了使用一种新的脂肪族和可生物降解的超支化聚酯（HBPE）从容易获得的丙二酸二乙酯合成。聚合物的球形结构具有功能性表面羧基和存在于聚合物内部的疏水空腔，允许形成多功能聚合物纳米颗粒，其能够包封多种疏水货物。通过简单的表面化学修饰，表面羧酸基团被修饰以产生具有各种表面官能化的纳米颗粒，例如氨基、叠氮基和炔丙基基团，其介导小分子的缀合。这种能力实现了HBPE纳米颗粒表面的工程化，用于特定的细胞内化研究和纳米颗粒组装体的形成，用于产生保留并且在某些情况下增强了亲本纳米颗粒构建块的性质的新型纳米复合材料。考虑到这些结果，HBPE聚合物、纳米颗粒和复合材料应该是生物医学、制药、纳米光子学和材料应用的理想选择。
Herein we report the design and synthesis of multifunctional hyperbranched polyester-based nanoparticles and nanocomposites with properties ranging from magnetic, fluorescence, antioxidant and X-ray contrast. The fabrication of these nanostructures was achieved using a novel aliphatic and biodegradable hyperbranched polyester (HBPE) synthesized from readily available diethylmalonate. The polymer’s globular structure with functional surface carboxylic groups and hydrophobic cavities residing in the polymer’s interior allows for the formation of multifunctional polymeric nanoparticles, which are able to encapsulate a diversity of hydrophobic cargos. Via simple surface chemistry modifications, the surface carboxylic acid groups were modified to yield nanoparticles with a variety of surface functionalizations, such as amino, azide and propargyl groups, which mediated the conjugation of small molecules. This capability achieved the engineering of the HBPE nanoparticle surface for specific cell internalization studies and the formation of nanoparticle assemblies for the creation of novel nanocomposites that retained, and in some cases enhanced, the properties of the parental nanoparticle building blocks. Considering these results, the HBPE polymer, nanoparticles and composites should be ideal for biomedical, pharmaceutical, nanophotonics and material applications.
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影响因子：
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作者：
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通讯作者：
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