Pleiotropy of C-reactive protein gene polymorphisms with C-reactive protein levels and heart rate variability in healthy male twins.
Pleiotropy of C-reactive protein gene polymorphisms with C-reactive protein levels and heart rate variability in healthy male twins.
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DOI：
10.1016/j.amjcard.2009.07.063
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发表时间：
2009-12-15
影响因子：
2.8
通讯作者：
Vaccarino, Viola
中科院分区：
文献类型：
--
作者：
Su, Shaoyong;Lampert, Rachel;Zhao, Jinying;Bremner, James Douglas;Miller, Andrew;Snieder, Harold;Lee, Forrester;Khan, Durreshahwar;Goldberg, Jack;Vaccarino, Viola
心率变异性(HRV)降低和C反应蛋白(CRP)水平升高都是冠状动脉疾病(CAD)的预测指标，并且相互关联。我们检查了这两种表型是否有共同的遗传底物，并调查了CRP基因多态与CRP水平和HRV指数的关系。我们检查了236对无症状性冠心病的男性双胞胎，平均年龄(±SD)为54岁(±2.9)。用24小时心电记录测量血浆CRP水平和心率变异性的频域测量，包括超低、极低、低频和高频功率(超低频、甚低频、低频和高频)。对C反应蛋白基因的3个SNPs进行了基因分型。使用广义估计方程来检验CRP和HRV之间的关联，以及基因-表型关联。采用双变量结构方程模型估计了C反应蛋白与心率变异性的遗传和环境相关性，以及C反应蛋白基因多态性对C反应蛋白-心率变异性关联的解释作用。C反应蛋白(H_2=0.76)和心率变异性指数(H_2=0.56~0.64)均具有较高的遗传度。较高的CRP水平与较低的HRV显著相关。C反应蛋白与URF之间有很强的遗传相关性(Rg=−0.3，P=0.001)。1个CRPSNP(Rs1205)与CRP值(P=0.003)和ULF(P=0.005)均显著相关，可解释两者间11%的遗传协方差。总而言之，HRV降低与CRP血浆水平升高显著相关，这种相关性在很大程度上是由于共同的遗传影响。C反应蛋白基因的多态对C反应蛋白水平和心率变异性均有影响。
Reduced heart rate variability (HRV) and increased C-reactive protein (CRP) levels are both predictors of coronary artery disease (CAD), and are correlated with each other. We examined whether these two phenotypes share a common genetic substrate and investigated the relations of the CRP gene polymorphisms with both CRP levels and HRV indices. We examined 236 male twins free of symptomatic CAD, with mean age (±SD) of 54 years (±2.9). Plasma CRP levels were measured and frequency domain measures of HRV were assessed using a 24-hour ECG recording, including ultra-low, very-low, low and high frequency power (ULF, VLF, LF, and HF). Three SNPs in the CRP gene were genotyped. Generalized estimating equations were used to examine the association between CRP and HRV, as well as the genotype-phenotype association. Bivariate structural equation modeling was performed to estimate the genetic and environmental correlations between CRP and HRV, and the explanatory effect of CRP gene polymorphisms on the CRP-HRV association. Both CRP (h2=0.76) and HRV indices (h2=0.56–0.64) showed high heritability. Higher CRP levels were significantly associated with lower HRV. A robust genetic correlation was found between CRP and ULF (rG=−0.3, P=0.001). One CRP SNP (rs1205) was significantly associated with both CRP (P=0.003) and ULF (P=0.005) and explained 11% of the genetic covariance between them. In conclusion, reduced HRV is significantly correlated with increased CRP plasma levels and this correlation is due, in large part, to common genetic influences. A polymorphism in the CRP gene contributes to both CRP levels and HRV.
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影响因子：
3.5
作者：
Russell AI;Cunninghame Graham DS;Shepherd C;Roberton CA;Whittaker J;Meeks J;Powell RJ;Isenberg DA;Walport MJ;Vyse TJ
通讯作者：
Vyse TJ
影响因子：
37.8
作者：
Kupper, NHM;Willemsen, G;de Geus, EJC
通讯作者：
de Geus, EJC
DOI：
10.1375/twin.5.5.476
发表时间：
2002-10-01
期刊：
TWIN RESEARCH
影响因子：
--
作者：
Goldberg, J;Curran, B;Boyko, EJ
通讯作者：
Boyko, EJ
影响因子：
4.8
作者：
Lampert, Rachel;Bremner, J. Douglas;Vaccarino, Viola
通讯作者：
Vaccarino, Viola
影响因子：
2.8
作者：
Lanza, GA;Sgueglia, GA;Maseri, A
通讯作者：
Maseri, A