Steroids and injury to the developing brain: net harm or net benefit?
Steroids and injury to the developing brain: net harm or net benefit?
复制标题
DOI：
10.1016/j.clp.2013.09.006
复制
发表时间：
2014-03
影响因子：
2.1
通讯作者：
Stonestreet BS
中科院分区：
文献类型：
--
作者：
Malaeb SN;Stonestreet BS
糖皮质激素，通常被称为类固醇，被广泛用于围产期医学。它们被开给有早产风险的孕妇，有时也开给患有严重气道或肺部疾病、难治性低血压或感染性休克的婴儿。早产儿脑损伤、发病率和死亡率的风险很高。类固醇被认为可以减轻其中一些风险。1，2然而，使用的类固醇方案差异很大，从妊娠晚期早期给予母亲的产前类固醇的单一短期疗程，到早产儿在数周内给予类固醇的重复或延长疗程。随着越来越多的数据积累了关于婴儿暴露于类固醇的长期结果，人们越来越担心在某些情况下暴露于类固醇后神经发育障碍。本文总结了一些实验和临床发现，并探讨了类固醇和脑损伤之间的关系的复杂性，重点是早产儿的大脑。
Glucocorticoids, commonly referred to as steroids, are widely used in neonatalperinatal medicine. They are prescribed to pregnant women at risk for premature birth, and sometimes to infants with significant airway or lung disease, refractory hypotension, or septic shock. Preterm infants are at high risk for brain injury, morbidity, and mortality. Steroids are thought to attenuate some of these risks. 1, 2 However, steroid regimens used vary widely, from a single short course of antenatal steroids given to the mother early in the third trimester, to repeated or prolonged courses of steroids given over weeks to the premature infant. As more data have accumulated regarding the long-term outcomes of infants exposed to steroids, concern has been increasing about neurodevelopmental impairment after exposure to steroids in certain settings. This article summarizes some of the experimental and clinical findings, and explores the complex nature of the relationship between steroids and brain injury, with a focus on the premature brain.
登录
查看更多内容
影响因子：
158.5
作者：
CUMMINGS, JJ;DEUGENIO, DB;GROSS, SJ
通讯作者：
GROSS, SJ
影响因子：
3.5
作者：
DIAMOND, DM;BENNETT, MC;ROSE, GM
通讯作者：
ROSE, GM
影响因子：
2.5
作者：
Elitt, CM;Sadowska, GB;Stonestreet, BS
通讯作者：
Stonestreet, BS
影响因子：
3.6
作者：
Benders MJ;Groenendaal F;van Bel F;Ha Vinh R;Dubois J;Lazeyras F;Warfield SK;Hüppi PS;de Vries LS
通讯作者：
de Vries LS
影响因子：
3.3
作者：
GOULD, E;WOOLLEY, CS;MCEWEN, BS
通讯作者：
MCEWEN, BS