Disease-associated metabolic alterations that impact satellite cells and muscle regeneration: perspectives and therapeutic outlook.
Disease-associated metabolic alterations that impact satellite cells and muscle regeneration: perspectives and therapeutic outlook.
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DOI：
10.1186/s12986-021-00565-0
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发表时间：
2021-03-25
影响因子：
4.5
通讯作者：
Doles JD
中科院分区：
文献类型：
--
作者：
Joseph J;Doles JD
许多慢性病患者经历瘦肌肉质量的同时损失。骨骼肌是一种动态的组织，由连续的蛋白质周转和祖细胞活性维持。肌肉干细胞或卫星细胞分化（通过一个称为肌生成的过程）并融合以修复和再生肌肉。在肌生成过程中，卫星细胞经历广泛的代谢改变;因此，以代谢紊乱为特征的病理学具有损害肌生成的潜力，并因此加剧骨骼肌萎缩。卫星细胞中与疾病相关的代谢中断如何可能导致浪费是一个很大程度上被忽视的重要问题。通过这篇综述，我们强调了疾病中各种代谢中断对肌肉发生和骨骼肌再生的影响。我们还讨论了有可能改善肌肉发生、骨骼肌再生并最终改善肌肉质量的代谢疗法。
Many chronic disease patients experience a concurrent loss of lean muscle mass. Skeletal muscle is a dynamic tissue maintained by continuous protein turnover and progenitor cell activity. Muscle stem cells, or satellite cells, differentiate (by a process called myogenesis) and fuse to repair and regenerate muscle. During myogenesis, satellite cells undergo extensive metabolic alterations; therefore, pathologies characterized by metabolic derangements have the potential to impair myogenesis, and consequently exacerbate skeletal muscle wasting. How disease-associated metabolic disruptions in satellite cells might be contributing to wasting is an important question that is largely neglected. With this review we highlight the impact of various metabolic disruptions in disease on myogenesis and skeletal muscle regeneration. We also discuss metabolic therapies with the potential to improve myogenesis, skeletal muscle regeneration, and ultimately muscle mass.
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影响因子：
2.7
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通讯作者：
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