Progress in understanding the role of lncRNA in programmed cell death.
Progress in understanding the role of lncRNA in programmed cell death.
复制标题
了解lncRNA在程序性细胞死亡中的作用取得进展
DOI：
10.1038/s41420-021-00407-1
复制
发表时间：
2021-02-08
影响因子：
7
通讯作者：
Shang L
中科院分区：
文献类型：
--
作者：
Jiang N;Zhang X;Gu X;Li X;Shang L
长链非编码RNA（lncRNA）是长度超过200个核苷酸但不翻译成蛋白质的转录物。LncRNA在多个水平调节基因表达，例如染色质、转录和转录后。此外，lncRNA参与各种生物过程，如细胞分化、细胞周期调控和干细胞多能性的维持。我们以前报道过lncRNA与程序性细胞死亡（PCD）密切相关，程序性细胞死亡包括凋亡、自噬、坏死性凋亡和铁凋亡。过表达lncRNA可通过下调细胞膜受体抑制外源性凋亡途径，并通过抑制坏死性凋亡相关蛋白的表达保护肿瘤细胞。一些lncRNA也可以作为竞争性内源性RNA来防止氧化，从而抑制铁凋亡，而一些已知激活自噬。lncRNA和PCD之间的关系在临床研究中具有有希望的意义，并且报告已经强调了在各种癌症如非小细胞肺癌和胃癌中的这种关系。本文系统地总结了lncRNA影响PCD的分子机制的研究进展。
Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides but not translated into proteins. LncRNAs regulate gene expressions at multiple levels, such as chromatin, transcription, and post-transcription. Further, lncRNAs participate in various biological processes such as cell differentiation, cell cycle regulation, and maintenance of stem cell pluripotency. We have previously reported that lncRNAs are closely related to programmed cell death (PCD), which includes apoptosis, autophagy, necroptosis, and ferroptosis. Overexpression of lncRNA can suppress the extrinsic apoptosis pathway by downregulating of membrane receptors and protect tumor cells by inhibiting the expression of necroptosis-related proteins. Some lncRNAs can also act as competitive endogenous RNA to prevent oxidation, thereby inhibiting ferroptosis, while some are known to activate autophagy. The relationship between lncRNA and PCD has promising implications in clinical research, and reports have highlighted this relationship in various cancers such as non-small cell lung cancer and gastric cancer. This review systematically summarizes the advances in the understanding of the molecular mechanisms through which lncRNAs impact PCD.
登录
查看更多内容
伴侣介导的自噬的时代的到来。
DOI：
10.1038/s41580-018-0001-6
发表时间：
2018-06
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Kaushik S;Cuervo AM
通讯作者：
Cuervo AM
c-Jun N 末端激酶通过其激酶依赖性和独立性活性来差异调节 TNF 和 TLR 介导的坏死性凋亡。
影响因子：
9
作者：
Cao M;Chen F;Xie N;Cao MY;Chen P;Lou Q;Zhao Y;He C;Zhang S;Song X;Sun Y;Zhu W;Mou L;Luan S;Gao H
通讯作者：
Gao H
影响因子：
4.8
作者：
Kaiser, William J.;Sridharan, Haripriya;Mocarski, Edward S.
通讯作者：
Mocarski, Edward S.
影响因子：
64.8
作者：
Jiang, Le;Kon, Ning;Li, Tongyuan;Wang, Shang-Jui;Su, Tao;Hibshoosh, Hanina;Baer, Richard;Gu, Wei
通讯作者：
Gu, Wei
影响因子：
19
作者：
Kaushik S;Cuervo AM
通讯作者：
Cuervo AM