Elastic Deformation of Soft Tissue-Mimicking Materials Using a Single Microbubble and Acoustic Radiation Force.
Elastic Deformation of Soft Tissue-Mimicking Materials Using a Single Microbubble and Acoustic Radiation Force.
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DOI：
10.1016/j.ultrasmedbio.2020.08.012
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发表时间：
2020-12
影响因子：
2.9
通讯作者：
Choi JJ
中科院分区：
文献类型：
--
作者：
Bezer JH;Koruk H;Rowlands CJ;Choi JJ
微泡对组织的机械效应是许多新兴超声应用的核心。在这里，我们研究了在临床相关的治疗超声参数下，微泡对组织施加的声辐射力。将单个微泡放入无壁水凝胶通道（直径：25-100µm，杨氏模量：2-8.7 kPa）中，暴露于声脉冲（中心频率：1 MHz，脉冲长度：10 ms，峰值反射压力：0.6-1.0 MPa）中。使用高速显微镜，每个微泡被跟踪，因为它推动水凝胶壁。我们发现，单个微泡可以使软组织模拟材料瞬间变形几微米，产生的组织加载-卸载曲线与使用其他基于压痕的方法产生的曲线相似。压痕深度与凝胶硬度有关。利用与变形曲线拟合的数学模型，我们估计了每个气泡（通常为几十纳米牛顿）的辐射力和凝胶的粘度。这些结果提供了对超声治疗期间施加在组织上的力的深入了解，并指出了生物效应的潜在来源。
Mechanical effects of microbubbles on tissues are central to many emerging ultrasound applications. Here, we investigated the acoustic radiation force a microbubble exerts on tissue at clinically relevant therapeutic ultrasound parameters. Individual microbubbles administered into a wall-less hydrogel channel (diameter: 25–100 µm, Young's modulus: 2–8.7 kPa) were exposed to an acoustic pulse (centre frequency: 1 MHz, pulse length: 10 ms, peak-rarefactional pressures: 0.6–1.0 MPa). Using high-speed microscopy, each microbubble was tracked as it pushed against the hydrogel wall. We found that a single microbubble can transiently deform a soft tissue-mimicking material by several micrometres, producing tissue loading–unloading curves that were similar to those produced using other indentation-based methods. Indentation depths were linked to gel stiffness. Using a mathematical model fitted to the deformation curves, we estimated the radiation force on each bubble (typically tens of nanonewtons) and the viscosity of the gels. These results provide insight into the forces exerted on tissues during ultrasound therapy and indicate a potential source of bio-effects.
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DOI：
10.1073/pnas.1105116108
发表时间：
2011-10-04
影响因子：
11.1
作者：
Choi, James J.;Selert, Kirsten;Konofagou, Elisa E.
通讯作者：
Konofagou, Elisa E.
DOI：
10.1109/tuffc.2018.2847899
发表时间：
2018-12-01
影响因子：
3.6
作者：
Blue, Lauchlin M.;Guidi, Francesco;Tortoli, Piero
通讯作者：
Tortoli, Piero
影响因子：
10.6
作者：
Christensen-Jeffries, Kirsten;Browning, Richard J.;Eckersley, Robert J.
通讯作者：
Eckersley, Robert J.
DOI：
10.1109/tuffc.2005.1504019
发表时间：
2005-06-01
影响因子：
3.6
作者：
Erpelding, TN;Hollman, KW;O'Donnell, M
通讯作者：
O'Donnell, M
影响因子：
3.3
作者：
Abou-Elkacem L;Bachawal SV;Willmann JK
通讯作者：
Willmann JK