Association between low plasma tryptophan and blackouts in male alcoholic patients.
Association between low plasma tryptophan and blackouts in male alcoholic patients.
复制标题
低血浆色氨酸与男性酒精患者昏厥之间的关联。
DOI：
10.1111/j.1530-0277.1985.tb05569.x
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Lieber,CS
中科院分区：
文献类型：
--
作者：
Branchey,L;Branchey,M;Zucker,D;Shaw,S;Lieber,CS
据观察，酒精会改变记忆功能的各个方面。酗酒者经历的一些最极端的记忆损害形式是昏迷。目前，关于酒精引起的记忆损害的生物学机制的资料很少，包括胆碱能和儿茶酚胺能系统在内的多种机制都与学习和记忆有关。然而，最近，5-羟色胺能系统在记忆功能中的重要性已经被证明。我们调查了有昏迷病史的患者是否比没有昏迷病史的患者血浆5-羟色胺前体色氨酸水平更低。有过昏迷经历的患者的色氨酸值显着低于没有经历过昏迷的患者，两组患者之间没有观察到与色氨酸共享同一运输载体进入大脑的其他氨基酸的显着差异。饮酒史变量在两组患者中没有区别。我们的数据表明，血浆色氨酸的减少(以及随之而来的大脑5-羟色胺的降低)可能会增加某些人在记忆障碍的各个方面表现出来的易感性，记忆障碍是最极端的形式之一，即昏迷
Alcohol has been observed to alter various aspects of memory function. Some of the most extreme forms of memory impairment experienced by alcoholics are blackouts. There are at present very few data on the biological mechanisms underlying alcohol‐related memory impairment A variety of mechanisms including the cholinergic and catecholaminergic systems have been implicated in learning and memory. More recently, however, the importance of the serotonergic system in memory function has been demonstrated. We investigated whether patients with a history of blackouts had lower plasma levels of the serotonin precursor tryptophan than patients without such a history. Tryptophan values were significantly lower in patients who had experienced blackouts than in patients who had not No significant differences between the two group of patients were observed for other amino adds sharing with tryptophan the same transport carrier into the brain. Drinking history variables did not differentiate among the two patient groups. Our data suggest that a decrease in plasma tryptophan (and concomitant lowered brain serotonin) could increase the vulnerability of certain individuals to manifestations of various aspects of memory impairment mdudrng one of its most extreme forms, the blackout
登录
查看更多内容
影响因子：
4.7
作者：
W. Pardridge;W. Oldendorf
通讯作者：
W. Oldendorf
影响因子：
--
作者：
R. Ryback
通讯作者：
R. Ryback
酒精和记忆：检索过程。
DOI：
10.1016/s0022-5371(78)90210-4
发表时间：
1978
期刊：
Journal of Verbal Learning and Verbal Behavior
影响因子：
--
作者：
I. Birnbaum;E. S. Parker;J. Hartley;E. Noble
通讯作者：
E. Noble
大量摄入乙醇后，人体血浆氨基酸减少。
DOI：
--
发表时间：
1983
期刊：
Journal of Studies on Alcohol
影响因子：
--
作者：
T. Eriksson;T. Magnusson;A. Carlsson;M. Hagman;R. Jagenburg
通讯作者：
R. Jagenburg
酒精和记忆：实验诱导中毒期间的健忘症和短期记忆功能。
影响因子：
17.7
作者：
J. Tamerin;S. Weiner;R. Poppen;P. Steinglass;J. Mendelson
通讯作者：
J. Mendelson