Phosphorylation and Reorganization of Keratin Networks: Implications for Carcinogenesis and Epithelial Mesenchymal Transition.
Phosphorylation and Reorganization of Keratin Networks: Implications for Carcinogenesis and Epithelial Mesenchymal Transition.
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DOI：
10.4062/biomolther.2015.032
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发表时间：
2015-07
影响因子：
3.7
通讯作者：
Lee CH
中科院分区：
文献类型：
--
作者：
Kim HJ;Choi WJ;Lee CH
转移是癌症的标志之一，也是癌症死亡的主要原因。对抗转移是非常具有挑战性的。为了克服这些困难，研究人员专注于转移性癌细胞的物理特性。来自患者的转移性癌细胞比良性癌细胞或正常细胞更柔软。癌细胞粘弹性的变化与角蛋白网络有关。出乎意料的是，角蛋白网络是动态的，角蛋白网络的调节对于癌症的转移是重要的。角蛋白由I型和II型杂聚物组成。角蛋白从质膜连接到细胞核。包括激酶和蛋白磷酸酶在内的几种蛋白质与角蛋白中间丝结合。几种内源性化合物或毒性化合物诱导癌细胞中角蛋白网络的磷酸化和重组，导致迁移增加。角蛋白的持续磷酸化导致角蛋白的丢失，这是上皮间质转化（EMT）的特征之一。因此，参与角蛋白磷酸化和重组的几种蛋白质也在EMT中起作用。控制角蛋白磷酸化和重组的化合物可能是对抗EMT和转移的潜在候选物。
Metastasis is one of hallmarks of cancer and a major cause of cancer death. Combatting metastasis is highly challenging. To overcome these difficulties, researchers have focused on physical properties of metastatic cancer cells. Metastatic cancer cells from patients are softer than benign cancer or normal cells. Changes of viscoelasticity of cancer cells are related to the keratin network. Unexpectedly, keratin network is dynamic and regulation of keratin network is important to the metastasis of cancer. Keratin is composed of heteropolymer of type I and II. Keratin connects from the plasma membrane to nucleus. Several proteins including kinases, and protein phosphatases bind to keratin intermediate filaments. Several endogenous compounds or toxic compounds induce phosphorylation and reorganization of keratin network in cancer cells, leading to increased migration. Continuous phosphorylation of keratin results in loss of keratin, which is one of the features of epithelial mesenchymal transition (EMT). Therefore, several proteins involved in phosphorylation and reorganization of keratin also have a role in EMT. It is likely that compounds controlling phosphorylation and reorganization of keratin are potential candidates for combating EMT and metastasis.
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影响因子：
24.5
作者：
Govaere O;Komuta M;Berkers J;Spee B;Janssen C;de Luca F;Katoonizadeh A;Wouters J;van Kempen LC;Durnez A;Verslype C;De Kock J;Rogiers V;van Grunsven LA;Topal B;Pirenne J;Vankelecom H;Nevens F;van den Oord J;Pinzani M;Roskams T
通讯作者：
Roskams T
角蛋白8磷酸化的丧失导致肿瘤进展增加，并与OSCC患者的临床病理参数相关。
影响因子：
3.7
作者：
Alam H;Gangadaran P;Bhate AV;Chaukar DA;Sawant SS;Tiwari R;Bobade J;Kannan S;D'cruz AK;Kane S;Vaidya MM
通讯作者：
Vaidya MM
影响因子：
3.7
作者：
Grin B;Mahammad S;Wedig T;Cleland MM;Tsai L;Herrmann H;Goldman RD
通讯作者：
Goldman RD
影响因子：
7.8
作者：
BARIBAULT, H;BLOUIN, R;MARCEAU, N
通讯作者：
MARCEAU, N
影响因子：
3.6
作者：
Fortier, Anne-Marie;Riopel, Kathleen;Cadrin, Monique
通讯作者：
Cadrin, Monique