Telehealth-Based Music Therapy Versus Cognitive Behavioral Therapy for Anxiety in Cancer Survivors: Rationale and Protocol for a Comparative Effectiveness Trial.
Telehealth-Based Music Therapy Versus Cognitive Behavioral Therapy for Anxiety in Cancer Survivors: Rationale and Protocol for a Comparative Effectiveness Trial.
复制标题
DOI：
10.2196/46281
复制
发表时间：
2023-04-27
影响因子：
1.7
通讯作者：
Mao, Jun J.
中科院分区：
文献类型：
--
作者：
Liou, Kevin;McConnell, Kelly M.;Currier, M. Beatriz;Baser, Raymond E.;MacLeod, Jodi;Walker, Desiree;Casaw, Camila;Wong, Greta;Piulson, Lauren;Popkin, Karen;Lopez, Ana Maria;Panageas, Katherine;Bradt, Joke;Mao, Jun J.
关键词：
癌症幸存者是美国增长最快的人群之一。不幸的是，近三分之一的幸存者由于癌症及其治疗的长期后果而出现焦虑症状。焦虑以不安、肌肉紧张和忧虑为特征，使生活质量恶化；损害日常功能；它与睡眠质量差、情绪低落和疲劳有关。虽然药物治疗的选择是可用的，多药已成为日益关注的癌症幸存者。音乐疗法（MT）和认知行为疗法（CBT）是基于证据的非药物治疗方法，在治疗癌症人群的焦虑症状方面已被证明有效，并且可以适应远程交付，以增加获得心理健康治疗的机会。然而，通过远程医疗提供的这两种干预措施的相对有效性尚不清楚。音乐疗法与认知行为疗法治疗癌症相关焦虑（MELODY）研究的目的是确定基于远程医疗的MT与基于远程医疗的CBT对癌症幸存者焦虑和共病症状的比较效果，并确定与MT和CBT更大程度减轻焦虑症状相关的患者水平因素。MELODY研究是一项双组、平行组随机临床试验，旨在比较MT与CBT治疗焦虑和共病症状的有效性。该试验将招募300名英语或西班牙语的任何癌症类型或阶段的幸存者，他们经历过至少一个月的焦虑症状。参与者将在7周内通过Zoom （Zoom Video Communications, Inc）远程提供每周7次的MT或CBT课程。评估焦虑（主要结局）、合并症（疲劳、抑郁、失眠、疼痛和认知功能障碍）和健康相关生活质量的有效工具将在基线和第4周、第8周（治疗结束）、第16周和第26周使用。半结构化访谈将在第8周对60名参与者（每个治疗组30人）的子样本进行，以了解治疗阶段的个人经历及其影响。第一位研究参与者于2022年2月入组。截至2023年1月，已有151名参与者注册。该试验预计将于2024年9月完成。这项研究是第一个也是最大的随机临床试验，比较远程提供MT和CBT治疗癌症幸存者焦虑的短期和长期有效性。局限性包括缺乏常规护理或安慰剂对照组，以及缺乏对试验参与者精神疾病的正式诊断评估。研究结果将有助于指导两种循证、可扩展和可获得的干预措施的治疗决策，以促进癌症幸存者期间的心理健康。derr1 - 10.2196/46281
Cancer survivors represent one of the fastest growing populations in the United States. Unfortunately, nearly 1 in 3 survivors experience anxiety symptoms as a long-term consequence of cancer and its treatment. Characterized by restlessness, muscle tension, and worry, anxiety worsens the quality of life; impairs daily functioning; and is associated with poor sleep, depressed mood, and fatigue. Although pharmacological treatment options are available, polypharmacy has become a growing concern for cancer survivors. Music therapy (MT) and cognitive behavioral therapy (CBT) are evidence-based, nonpharmacological treatments that have demonstrated effectiveness in treating anxiety symptoms in cancer populations and can be adapted for remote delivery to increase access to mental health treatments. However, the comparative effectiveness of these 2 interventions delivered via telehealth is unknown. The aims of the Music Therapy Versus Cognitive Behavioral Therapy for Cancer-related Anxiety (MELODY) study are to determine the comparative effectiveness of telehealth-based MT versus telehealth-based CBT for anxiety and comorbid symptoms in cancer survivors and to identify patient-level factors associated with greater anxiety symptom reduction for MT and CBT. The MELODY study is a 2-arm, parallel-group randomized clinical trial that aims to compare the effectiveness of MT versus CBT for anxiety and comorbid symptoms. The trial will enroll 300 English- or Spanish-speaking survivors of any cancer type or stage who have experienced anxiety symptoms for at least 1 month. Participants will receive 7 weekly sessions of MT or CBT delivered remotely via Zoom (Zoom Video Communications, Inc) over 7 weeks. Validated instruments to assess anxiety (primary outcome), comorbid symptoms (fatigue, depression, insomnia, pain, and cognitive dysfunction), and health-related quality of life will be administered at baseline and at weeks 4, 8 (end of treatment), 16, and 26. Semistructured interviews will be conducted at week 8 with a subsample of 60 participants (30 per treatment arm) to understand individual experiences with the treatment sessions and their impact. The first study participant was enrolled in February 2022. As of January 2023, 151 participants have been enrolled. The trial is expected to be completed by September 2024. This study is the first and largest randomized clinical trial to compare the short- and long-term effectiveness of remotely delivered MT and CBT for anxiety in cancer survivors. Limitations include the lack of usual care or placebo control groups and the lack of formal diagnostic assessments for psychiatric disorders among trial participants. The study findings will help guide treatment decisions for 2 evidence-based, scalable, and accessible interventions to promote mental well-being during cancer survivorship. DERR1-10.2196/46281
登录
查看更多内容
影响因子：
3.7
作者：
Andrews G;Cuijpers P;Craske MG;McEvoy P;Titov N
通讯作者：
Titov N
影响因子：
1.9
作者：
Bender, Catherine M.;Gentry, Amanda L.;Sereika, Susan M.
通讯作者：
Sereika, Susan M.
DOI：
10.1080/24740527.2017.1384297
发表时间：
2017-01-01
影响因子：
2.4
作者：
Beasley, Marcus John;Ferguson-Jones, Elizabeth Alice;Macfarlane, Gary John
通讯作者：
Macfarlane, Gary John
影响因子：
45.3
作者：
Andersen, Barbara L.;DeRubeis, Robert J.;Rowland, Julia H.
通讯作者：
Rowland, Julia H.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y