Genotype- and Age-Dependent Differences in Ultrasound Vocalizations of SPRED2 Mutant Mice Revealed by Machine Deep Learning.
Genotype- and Age-Dependent Differences in Ultrasound Vocalizations of SPRED2 Mutant Mice Revealed by Machine Deep Learning.
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机器深度学习揭示 SPRED2 突变小鼠超声发声的基因型和年龄依赖性差异。
DOI：
10.3390/brainsci11101365
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发表时间：
2021-10-17
期刊：
影响因子：
3.3
通讯作者：
Schuh K
中科院分区：
文献类型：
--
作者：
Hepbasli D;Gredy S;Ullrich M;Reigl A;Abeßer M;Raabe T;Schuh K
Vocalization is an important part of social communication, not only for humans but also for mice. Here, we show in a mouse model that functional deficiency of Sprouty-related EVH1 domain-containing 2 (SPRED2), a protein ubiquitously expressed in the brain, causes differences in social ultrasound vocalizations (USVs), using an uncomplicated and reliable experimental setting of a short meeting of two individuals. SPRED2 mutant mice show an OCD-like behaviour, accompanied by an increased release of stress hormones from the hypothalamic–pituitary–adrenal axis, both factors probably influencing USV usage. To determine genotype-related differences in USV usage, we analyzed call rate, subtype profile, and acoustic parameters (i.e., duration, bandwidth, and mean peak frequency) in young and old SPRED2-KO mice. We recorded USVs of interacting male and female mice, and analyzed the calls with the deep-learning DeepSqueak software, which was trained to recognize and categorize the emitted USVs. Our findings provide the first classification of SPRED2-KO vs. wild-type mouse USVs using neural networks and reveal significant differences in their development and use of calls. Our results show, first, that simple experimental settings in combination with deep learning are successful at identifying genotype-dependent USV usage and, second, that SPRED2 deficiency negatively affects the vocalization usage and social communication of mice.
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影响因子：
2.5
作者：
Arriaga, Gustavo;Jarvis, Erich D.
通讯作者：
Jarvis, Erich D.
影响因子：
11
作者：
Ullrich M;Weber M;Post AM;Popp S;Grein J;Zechner M;Guerrero González H;Kreis A;Schmitt AG;Üçeyler N;Lesch KP;Schuh K
通讯作者：
Schuh K
影响因子：
3
作者：
Chabout J;Sarkar A;Dunson DB;Jarvis ED
通讯作者：
Jarvis ED
影响因子：
4.8
作者：
Bundschu, K;Knobeloch, KP;Schuh, K
通讯作者：
Schuh, K
影响因子：
1.4
作者：
MAGGIO, JC;WHITNEY, G
通讯作者：
WHITNEY, G