Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis.
Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis.
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DOI：
10.3390/ijms22126493
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发表时间：
2021-06-17
影响因子：
5.6
通讯作者：
Ganz T
中科院分区：
文献类型：
--
作者：
Nemeth E;Ganz T
尽管铁在环境中含量丰富，但生物可利用性很差，大多数生物必须严格保护和内部回收。在脊椎动物中，血浆和细胞外液中铁浓度的稳定性以及全身铁含量的稳定是通过铁调节多肽激素海普西丁与其受体和细胞铁出口蛋白(SLC40a1)相互作用来维持的。铁门蛋白从吸收膳食铁的十二指肠肠上皮细胞、脾和肝脏中的铁循环巨噬细胞以及储存铁的肝细胞中排出铁。海普西丁通过铁蛋白阻止铁的输出，导致低铁血症。在缺铁或出血后，海普西丁减少，以允许铁通过铁蛋白输送到血浆，从而促进代偿性红细胞生成。作为一种宿主防御介质，海普西丁增加了对感染和炎症的反应，阻止了铁通过铁蛋白输送到血浆中，从而限制了入侵微生物对铁的利用。遗传性疾病减少了海普西丁的合成或破坏了海普西丁与铁蛋白的结合，导致了铁超载紊乱遗传性血色素沉着症。相反的表型，铁限制或缺铁，可由基因或炎症性过度生产的海普西丁引起。
Despite its abundance in the environment, iron is poorly bioavailable and subject to strict conservation and internal recycling by most organisms. In vertebrates, the stability of iron concentration in plasma and extracellular fluid, and the total body iron content are maintained by the interaction of the iron-regulatory peptide hormone hepcidin with its receptor and cellular iron exporter ferroportin (SLC40a1). Ferroportin exports iron from duodenal enterocytes that absorb dietary iron, from iron-recycling macrophages in the spleen and the liver, and from iron-storing hepatocytes. Hepcidin blocks iron export through ferroportin, causing hypoferremia. During iron deficiency or after hemorrhage, hepcidin decreases to allow iron delivery to plasma through ferroportin, thus promoting compensatory erythropoiesis. As a host defense mediator, hepcidin increases in response to infection and inflammation, blocking iron delivery through ferroportin to blood plasma, thus limiting iron availability to invading microbes. Genetic diseases that decrease hepcidin synthesis or disrupt hepcidin binding to ferroportin cause the iron overload disorder hereditary hemochromatosis. The opposite phenotype, iron restriction or iron deficiency, can result from genetic or inflammatory overproduction of hepcidin.
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影响因子：
30.3
作者：
Arezes J;Jung G;Gabayan V;Valore E;Ruchala P;Gulig PA;Ganz T;Nemeth E;Bulut Y
通讯作者：
Bulut Y
影响因子：
20.3
作者：
Jiang L;Wang J;Wang K;Wang H;Wu Q;Yang C;Yu Y;Ni P;Zhong Y;Song Z;Xie E;Hu R;Min J;Wang F
通讯作者：
Wang F
影响因子：
3.6
作者：
Beaumont, Carole;Delaby, Constance
通讯作者：
Delaby, Constance
影响因子：
20.3
作者：
Ganz, Tomas;Olbina, Gordana;Westerman, Mark
通讯作者：
Westerman, Mark
MiR-20b 下调体外和体内肠铁转运蛋白表达
影响因子：
6
作者：
Jiang, Shuxia;Fang, Xi;Zhao, Ruqian
通讯作者：
Zhao, Ruqian