A rat model for measuring the effectiveness of transcranial direct current stimulation using fMRI
A rat model for measuring the effectiveness of transcranial direct current stimulation using fMRI
复制标题
使用功能磁共振成像测量经颅直流电刺激有效性的大鼠模型
DOI：
10.1016/j.neulet.2011.01.004
复制
发表时间：
2011
影响因子：
2.5
通讯作者：
N. Hironaka
中科院分区：
文献类型：
--
作者：
Yuji Takano;T. Yokawa;Asami Masuda;Jun Niimi;Satoshi Tanaka;N. Hironaka
经颅直流电刺激（tDCS）是目前备受关注的无创脑刺激技术之一，但其作用机制尚不清楚。为了阐明其作用机制，我们建立了大鼠模型，并使用功能磁共振成像（fMRI）测量了其有效性。碳纤维电极被放置在头部额叶皮层上方作为阳极，在颈部作为阴极。在麻醉条件下，在基线记录后施加400或40 μ a电流刺激10min。400 μ a刺激显著增加额叶皮层和伏隔核的信号强度。这表明额叶皮层上的阳极tDCS诱导额叶皮层及其连接的大脑区域的神经元激活。
Transcranial direct current stimulation (tDCS) is one of the noteworthy noninvasive brain stimulation techniques, but the mechanism of its action remains unclear. With the aim of clarifying the mechanism, we developed a rat model and measured its effectiveness using fMRI. Carbon fiber electrodes were placed on the top of the head over the frontal cortex as the anode and on the neck as the cathode. The stimulus was 400- or 40-μA current applied for 10min after a baseline recording under an anesthetized condition. The 400-μA stimulation significantly increased signal intensities in the frontal cortex and nucleus accumbens. This suggests anodal tDCS over the frontal cortex induces neuronal activation in the frontal cortex and in its connected brain region.
DOI：
10.1017/s1461145707007833
发表时间：
2008-03-01
影响因子：
4.8
作者：
Boggio, Paulo S.;Rigonatti, Sergio P.;Fregni, Felipe
通讯作者：
Fregni, Felipe